139446-70-1
Chemical Structure
PAI-1-derived peptide
Synonym(s): ARMAPE
- CAS No.: 139446-70-1
- Formula:C27H47N9O9S
- Molecular Weight:673.78
InChIKey: TYNGDHHMGWFOOJ-DYKIIFRCSA-N
SMILES: [H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)C)=O)CCSC)=O)=O)C
Biological Activity: PAI-1-derived peptide (ARMAPE) is a hexapeptide derived from the reactive center loop (RCL) of plasminogen activator inhibitor-1 (PAI-1). PAI-1-derived peptide can selectively bind to the PAI-1 binding site of t-PA without inactivating t-PA. PAI-1-derived peptide can be used to prepare linkers for t-PA/polymer conjugates. PAI-1-derived peptide competitively inhibits trypanosome endopeptidase[1][2][3][4].
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PAI-1-derived peptide | 98.55% | PAI-1-derived peptide (ARMAPE) is a hexapeptide derived from the reactive center loop (RCL) of plasminogen activator inhibitor-1 (PAI-1). PAI-1-derived peptide can selectively bind to the PAI-1 binding site of t-PA without inactivating t-PA. PAI-1-derived peptide can be used to prepare linkers for t-PA/polymer conjugates. PAI-1-derived peptide competitively inhibits trypanosome endopeptidase. | ||||||||||||||||||||
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References
- [1]. Zhan W, et al. Fabrication of Supramolecular Bioactive Surfaces via β-Cyclodextrin-Based Host-Guest Interactions. ACS applied materials & interfaces. 2018 Oct 31;10(43):36585-36601.
- [2]. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chemical communications (Cambridge, England). 2015 Sep 28;51(75):14263-6. [Content Brief]
- [3]. Kornblatt MJ, et al. Characterization of an endopeptidase of Trypanosoma brucei brucei. Arch Biochem Biophys. 1992 Feb 14;293(1):25-31. PMID: 1731636.
- [4]. Liu Q, et al. Surfaces having dual affinity for plasminogen and tissue plasminogen activator: in situ plasmin generation and clot lysis. Journal of materials chemistry. B. 2015 Sep 14;3(34):6939-6944.
