Growth Differentiation Factor-8 (GDF-8)
GDF-8, also known as Myostatin, belongs to TGFβ family. GDF-8 is highly expressed in skeletal muscle, and is a negative regulator of skeletal muscle growth. GDF-8 inhibits muscle growth, development, and regeneration. The lack of Myostatin shows a significant increase in muscle mass. GDF-8 circulates in the blood in a latent form, with an additional non-covalently bound propeptide at the N-terminus. Proteolytic cleavage of the propeptide by the BMP-1/tolloid family of metalloproteinases leads to activation of protein function. Similar to other TGF-β superfamily, GDF-8 binds to TGF-β type II receptor, type IIB activin receptor (ActRIIB) with high affinity, and regulates the expression of its target genes through a TGF-β signaling pathway. GDF-8 can activate the p38 MAPK, Erk1/2, and Wnt pathways[1][2][3].Human GDF-8 shares about 95% aa sequence identity with mouse and rats. Rat GDF-8 shares about 98% aa sequence identity with mouse.
- [1]. Elkasrawy MN, et al. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63. [Content Brief]
- [2]. Xie J, et al. GDF8 Promotes the Cell Invasiveness in Human Trophoblasts by Upregulating the Expression of Follistatin-Like 3 Through the ALK5-SMAD2/3 Signaling Pathway. Front Cell Dev Biol. 2020 Oct 28;8:573781. [Content Brief]
- [3]. Elkina Y, et al. The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):143-151. [Content Brief]
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Growth Differentiation Factor-8 (GDF-8) Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
