2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Growth Differentiation Factor
  6. Growth Differentiation Factor-8 (GDF-8)

Growth Differentiation Factor-8 (GDF-8)

Recombinant Protein Expression Service

Growth Differentiation Factor-8 (GDF-8)

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GDF-8, also known as Myostatin, belongs to TGFβ family. GDF-8 is highly expressed in skeletal muscle, and is a negative regulator of skeletal muscle growth. GDF-8 inhibits muscle growth, development, and regeneration. The lack of Myostatin shows a significant increase in muscle mass. GDF-8 circulates in the blood in a latent form, with an additional non-covalently bound propeptide at the N-terminus. Proteolytic cleavage of the propeptide by the BMP-1/tolloid family of metalloproteinases leads to activation of protein function. Similar to other TGF-β superfamily, GDF-8 binds to TGF-β type II receptor, type IIB activin receptor (ActRIIB) with high affinity, and regulates the expression of its target genes through a TGF-β signaling pathway. GDF-8 can activate the p38 MAPK, Erk1/2, and Wnt pathways[1][2][3].Human GDF-8 shares about 95% aa sequence identity with mouse and rats. Rat GDF-8 shares about 98% aa sequence identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72632
    GDF-8 Protein, Human/Mouse/Rat (HEK293)

    Growth/differentiation factor 8; GDF-8; Myostatin; MSTN

    		Rat HEK293
    GDF-8 (Growth Differentiation Factor 8) functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation. GDF-8 Protein, Human/Mouse/Rat (HEK293) is the recombinant rat-derived GDF-8 protein, expressed by HEK293, with tag free. The total length of GDF-8 Protein, Human/Mouse/Rat (HEK293) is 114 a.a., with molecular weight of 12-15 kDa.
  • HY-P74127
    GDF-8 Protein, Mouse (HEK293, Fc)

    Growth/differentiation factor 8; GDF-8; Myostatin; MSTN

    		Mouse HEK293
    The GDF-8 protein, also known as myostatin, negatively regulates skeletal muscle growth. It acts as a disulfide-linked homodimer and inhibits its activity by interacting with WFIKKN2. Additionally, it interacts with FSTL3. GDF-8 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GDF-8 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GDF-8 Protein, Mouse (HEK293, Fc) is 109 a.a., with molecular weight of ~45 kDa.
  • HY-P700498
    MSTN Protein, Cat (HEK293, His)

    myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8

    		Cat HEK293
    MSTN (Myostatin) serves as a dedicated negative regulator of skeletal muscle growth, forming homodimers through disulfide linkages. It inhibits WFIKKN2 activity through interaction and further contributes to its role in negatively modulating skeletal muscle growth by engaging with FSTL3. MSTN Protein, Cat (HEK293, His) is the recombinant cat-derived MSTN protein, expressed by HEK293, with N-10*His labeled tag. The total length of MSTN Protein, Cat (HEK293, His) is 357 a.a., with molecular weight of 44.2 kDa.
Cat. No. Product Name Effect Purity