2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Growth Differentiation Factor
  6. Growth Differentiation Factor 5 (GDF-5)

Growth Differentiation Factor 5 (GDF-5)

Recombinant Protein Expression Service

Growth Differentiation Factor 5 (GDF-5)

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GDF-5 belongs to TGFβ superfamily. GDF-5 is essential for cartilage development and homeostasis, and GDF-5 deficiency is associated with osteoarthritis (OA). Specifically, GDF-5 has high binding affinity to BMPR-IB, BMPR-II and Activin type II receptors. Upon binding to the receptors, the signalling cascade of GDF-5 activates the downstream Smad pathway. The phosphorylated Smad 1/5/8 then forms the complex with Smad 4 and translocates into the nucleus, thereby regulating cellular processes, such as proliferation, differentiation and synthesis of the ECM[1]. GDF-5 can modulate the initial stages of chondrogenesis (the mesenchymal condensations by increasing cell adhesion), or increase chondrocyte proliferation during skeletal development[2]. Human GDF-5 shares about 91% aa sequence identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72633
    GDF-5 Protein, Human

    Growth/differentiation factor 5; GDF-5; BMP-14; CDMP-1; LAP-4; Radotermin; CDMP1

    		Human E. coli
    The GDF-5 protein is critical in bone and cartilage formation, complexly regulating chondrogenic tissue differentiation through dual pathways. It positively affects cartilage formation by inducing SMAD protein signaling by binding to BMPR1B and BMPR1A. GDF-5 Protein, Human is the recombinant human-derived GDF-5 protein, expressed by E. coli , with tag free.
  • HY-P700023AF
    Animal-Free GDF-5 Protein, Human (His)

    Cartilage-Derived Morphogenetic Protein-1; Growth/Differentiation Factor-5; GDF-5; CDMP-1

    		Human E. coli
    The GDF-5 protein is critical in bone and cartilage formation, complexly regulating chondrogenic tissue differentiation through dual pathways. It positively affects cartilage formation by inducing SMAD protein signaling by binding to BMPR1B and BMPR1A. Animal-Free GDF-5 Protein, Human (His) is the recombinant human-derived animal-FreeGDF-5 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.
Cat. No. Product Name Effect Purity