Growth Differentiation Factor 5 (GDF-5)
GDF-5 belongs to TGFβ superfamily. GDF-5 is essential for cartilage development and homeostasis, and GDF-5 deficiency is associated with osteoarthritis (OA). Specifically, GDF-5 has high binding affinity to BMPR-IB, BMPR-II and Activin type II receptors. Upon binding to the receptors, the signalling cascade of GDF-5 activates the downstream Smad pathway. The phosphorylated Smad 1/5/8 then forms the complex with Smad 4 and translocates into the nucleus, thereby regulating cellular processes, such as proliferation, differentiation and synthesis of the ECM[1]. GDF-5 can modulate the initial stages of chondrogenesis (the mesenchymal condensations by increasing cell adhesion), or increase chondrocyte proliferation during skeletal development[2]. Human GDF-5 shares about 91% aa sequence identity with mouse.
- [1]. Sun K, et al. Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate. Cell Prolif. 2021 Mar;54(3):e12998. [Content Brief]
- [2]. Francis-West PH, et al. Mechanisms of GDF-5 action during skeletal development. Development. 1999 Mar;126(6):1305-15. [Content Brief]
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Growth Differentiation Factor 5 (GDF-5) Recombinant Proteins (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
