2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Bone Morphogenetic Proteins (BMPs) Growth Differentiation Factor
  6. BMP-9/GDF-2

BMP-9/GDF-2

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BMP-9 is also known as growth differentiation factor-2 (GDF-2). BMP-9 belongs to TGFβ superfamily and signals through ALK1. BMP-9 is a vascular quiescence factor maintaining endothelial homeostasis[1]. BMP-9 binds to ALK1 with a very high affinity (Kd: 29 nM). BMP-9 is mainly produced by the liver, specifically by hepatocytes, and at a lower level by the lungs and the brain[2]. BMP-9 also induces bone formation. Specifically, the activation of ALK1 will eventually lead to phosphorylation and heterodimeric formation of Smad proteins. These Smads proteins can then interact with Smad4 for proper nuclear localization, which is necessary for proper BMP9-induced osteogenic differentiation[3]. Human BMP-9 shares about 80% aa sequence identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P700033AF
    Animal-Free BMP-9/GDF-2 Protein, Human (His)

    GDF-2; BMP-9; GDF2; BMP9

    		Human E. coli
    BMP-9/GDF-2 Protein, a robust angiogenesis inhibitor, selectively signals through ACVRL1 in endothelial cells. Its signaling pathway requires the TGF-beta coreceptor endoglin/ENG for efficient activation of SMAD1. Existing as a homodimer with disulfide-linked structures, the protein forms complexes with ACVRL1, BMPR2, and ACVR2B, crucial for signal transduction. Additionally, it engages in high-affinity interactions with ENG, forming a heterotetramer or a heteromeric complex with ENG and ACVRL1. Notably, it interacts with the type I receptor ACVR1, contributing to the intricate regulatory network in the TGF-beta signaling pathway. Animal-Free BMP-9/GDF-2 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-9/GDF-2 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free BMP-9/GDF-2 Protein, Human (His) is 110 a.a., with molecular weight of ~12.89 kDa.
  • HY-P700530
    GDF-2 Protein, Human (P. pastoris, His)

    GDF-2; BMP-9; GDF2; BMP9

    		Human P. pastoris
    BMP-9/GDF-2 Protein, a robust angiogenesis inhibitor, selectively signals through ACVRL1 in endothelial cells. Its signaling pathway requires the TGF-beta coreceptor endoglin/ENG for efficient activation of SMAD1. Existing as a homodimer with disulfide-linked structures, the protein forms complexes with ACVRL1, BMPR2, and ACVR2B, crucial for signal transduction. Additionally, it engages in high-affinity interactions with ENG, forming a heterotetramer or a heteromeric complex with ENG and ACVRL1. Notably, it interacts with the type I receptor ACVR1, contributing to the intricate regulatory network in the TGF-beta signaling pathway. GDF-2 Protein, Human (P. pastoris, His) is the recombinant human-derived GDF-2 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of GDF-2 Protein, Human (P. pastoris, His) is 130 a.a., with molecular weight of 16.3 kDa.
  • HY-P77580
    BMP-9/GDF-2 Protein, Mouse (HEK293, Fc)

    GDF-2; BMP-9; GDF2; BMP9

    		Mouse HEK293
    The BMP-9/GDF-2 protein is a potent inhibitor of angiogenesis that signals through AVRL1, and endoglin/ENG is required for SMAD1 signaling in endothelial cells. As a homodimer with a disulfide-linked structure, BMP-9/GDF-2 forms a complex with AVRL1, BMPR2, and ACVR2B, which is critical for its signaling cascade. BMP-9/GDF-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived BMP-9/GDF-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BMP-9/GDF-2 Protein, Mouse (HEK293, Fc) is 110 a.a., with molecular weight of 47-50 kDa.
Cat. No. Product Name Effect Purity