BMP-9/GDF-2
BMP-9 is also known as growth differentiation factor-2 (GDF-2). BMP-9 belongs to TGFβ superfamily and signals through ALK1. BMP-9 is a vascular quiescence factor maintaining endothelial homeostasis[1]. BMP-9 binds to ALK1 with a very high affinity (Kd: 29 nM). BMP-9 is mainly produced by the liver, specifically by hepatocytes, and at a lower level by the lungs and the brain[2]. BMP-9 also induces bone formation. Specifically, the activation of ALK1 will eventually lead to phosphorylation and heterodimeric formation of Smad proteins. These Smads proteins can then interact with Smad4 for proper nuclear localization, which is necessary for proper BMP9-induced osteogenic differentiation[3]. Human BMP-9 shares about 80% aa sequence identity with mouse.
- [1]. Wei Z, et al. Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis. J Biol Chem. 2014 Nov 7;289(45):31150-9. [Content Brief]
- [2]. Tillet E, et al. Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia. Front Genet. 2015 Jan 8;5:456. [Content Brief]
- [3]. Mostafa S, et al. The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine. Genes Dis. 2019 Jul 24;6(3):201-223. [Content Brief]
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BMP-9/GDF-2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
