BMP-9/GDF-2

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BMP-9 is also known as growth differentiation factor-2 (GDF-2). BMP-9 belongs to TGFβ superfamily and signals through ALK1. BMP-9 is a vascular quiescence factor maintaining endothelial homeostasis^[1]. BMP-9 binds to ALK1 with a very high affinity (K_d: 29 nM). BMP-9 is mainly produced by the liver, specifically by hepatocytes, and at a lower level by the lungs and the brain^[2]. BMP-9 also induces bone formation. Specifically, the activation of ALK1 will eventually lead to phosphorylation and heterodimeric formation of Smad proteins. These Smads proteins can then interact with Smad4 for proper nuclear localization, which is necessary for proper BMP9-induced osteogenic differentiation^[3]. Human BMP-9 shares about 80% aa sequence identity with mouse.

References:

[1]. Wei Z, et al. Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis. J Biol Chem. 2014 Nov 7;289(45):31150-9. [Content Brief]

[2]. Tillet E, et al. Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia. Front Genet. 2015 Jan 8;5:456. [Content Brief]

[3]. Mostafa S, et al. The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine. Genes Dis. 2019 Jul 24;6(3):201-223. [Content Brief]

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BMP-9/GDF-2 Recombinant Proteins (3)

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (1) HEK293 (1) P. pastoris (1)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P700033AF

Animal-Free GDF-2/BMP-9 Protein, Human (His) GDF-2; BMP-9; GDF2; BMP9	Human	E. coli
The BMP-9/GDF-2 protein is a potent inhibitor of angiogenesis that selectively signals through AVRL1 in endothelial cells. Its signaling pathway requires the TGF-β coreceptor endoglin/ENG to effectively activate SMAD1. Animal-Free GDF-2/BMP-9 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-9/GDF-2 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700530

GDF-2/BMP-9 Protein, Human (P. pastoris, His) GDF-2; BMP-9; GDF2; BMP9	Human	P. pastoris
The BMP-9/GDF-2 protein is a potent inhibitor of angiogenesis that selectively signals through AVRL1 in endothelial cells. Its signaling pathway requires the TGF-β coreceptor endoglin/ENG to effectively activate SMAD1. GDF-2/BMP-9 Protein, Human (P. pastoris, His) is the recombinant human-derived GDF-2 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703981

GDF-2/BMP-9 Protein, Human (HEK293) GDF-2; GDF2; BMP-9; BMP9	Human	HEK293

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BMP-9/GDF-2

BMP-9/GDF-2

Subscribe Now to the List of Recombinant Proteins

BMP-9/GDF-2 Recombinant Proteins (3)