1. Immunology/Inflammation
  2. Salt-inducible Kinase (SIK)
  3. YKL-06-062

YKL-06-062 

Cat. No.: HY-129141
Handling Instructions

YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively. YKL-06-062 is the structural analog of YKL-06-062.

For research use only. We do not sell to patients.

YKL-06-062 Chemical Structure

YKL-06-062 Chemical Structure

CAS No. : 2172617-16-0

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2 mg USD 95 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively. YKL-06-062 is the structural analog of YKL-06-062[1].

In Vitro

YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner[1].

RT-PCR[1]

Cell Line: Human melanocyte cells, UACC62 melanoma cells
Concentration: 0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM
Incubation Time: 3 hours
Result: Unregulated MITF mRNA expression.
Molecular Weight

525.69

Formula

C₃₁H₃₉N₇O

CAS No.

2172617-16-0

SMILES

O=C1N(C2CCCCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3CN1C6=C(C)C=CC=C6C

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

YKL-06-062Salt-inducible Kinase (SIK)Inhibitorinhibitorinhibit

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