2. Immunology/Inflammation
  3. Salt-inducible Kinase (SIK)
  4. MR22

MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells.

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MR22

MR22 Chemical Structure

CAS No. : 3027761-24-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

MR22 Related Antibodies

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Description

MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].

Molecular Weight

359.37

Formula

C18H19F2N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (278.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7826 mL 13.9132 mL 27.8265 mL
5 mM 0.5565 mL 2.7826 mL 5.5653 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7826 mL 13.9132 mL 27.8265 mL 69.5662 mL
5 mM 0.5565 mL 2.7826 mL 5.5653 mL 13.9132 mL
10 mM 0.2783 mL 1.3913 mL 2.7826 mL 6.9566 mL
15 mM 0.1855 mL 0.9275 mL 1.8551 mL 4.6377 mL
20 mM 0.1391 mL 0.6957 mL 1.3913 mL 3.4783 mL
25 mM 0.1113 mL 0.5565 mL 1.1131 mL 2.7826 mL
30 mM 0.0928 mL 0.4638 mL 0.9275 mL 2.3189 mL
40 mM 0.0696 mL 0.3478 mL 0.6957 mL 1.7392 mL
50 mM 0.0557 mL 0.2783 mL 0.5565 mL 1.3913 mL
60 mM 0.0464 mL 0.2319 mL 0.4638 mL 1.1594 mL
80 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8696 mL
100 mM 0.0278 mL 0.1391 mL 0.2783 mL 0.6957 mL
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MR22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR223027761-24-3MR 22MR-22Salt-inducible Kinase (SIK)ovarian cancer cellsInhibitorinhibitorinhibit

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