3027761-24-3
Chemical Structure
MR22
- CAS No.: 3027761-24-3
- Formula:C18H19F2N5O
- Molecular Weight:359.37
IUPAC Name: 8-(4-aminobutyl)-6-(2,5-difluorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIKey: VCZDFACOFNRTMG-UHFFFAOYSA-N
SMILES: CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F
Biological Activity: MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].
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MR22 | 99.76% | MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells. | ||||||||||||||||||||
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Keywords
