Lymphotactin/XCL1 Protein, Mouse
The XCL1 protein selectively attracts lymphocytes and its chemotactic effects are distinct from those of monocytes or neutrophils. XCL1 is critical in the thymus, where it mediates the accumulation of dendritic cells in the medulla and contributes significantly to the development of regulatory T cells and the establishment of self-tolerance. Lymphotactin/XCL1 Protein, Mouse is the recombinant mouse-derived Lymphotactin/XCL1 protein, expressed by E. coli, with tag free.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The XCL1 protein selectively attracts lymphocytes and its chemotactic effects are distinct from those of monocytes or neutrophils. XCL1 is critical in the thymus, where it mediates the accumulation of dendritic cells in the medulla and contributes significantly to the development of regulatory T cells and the establishment of self-tolerance. Lymphotactin/XCL1 Protein, Mouse is the recombinant mouse-derived Lymphotactin/XCL1 protein, expressed by E. coli, with tag free.
XCL1 protein exhibits chemotactic activity specifically for lymphocytes, distinguishing its effect from monocytes or neutrophils. Within the thymus, XCL1 plays a pivotal role in mediating the medullary accumulation of thymic dendritic cells. This involvement contributes significantly to the development of regulatory T cells, thereby playing a key role in the establishment of self-tolerance. The chemotactic properties of XCL1 for lymphocytes, coupled with its impact on thymic dendritic cells and regulatory T cell development, highlight its intricate role in orchestrating immune responses within the thymic microenvironment and, ultimately, in shaping immune tolerance mechanisms.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag Tag Free
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Accession
P47993 (V22-G114)
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Gene ID174371
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Molecular Construction
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N-term
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XCL1 (V22-G114)
Accession # P47993 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
XCL1; X-C Motif Chemokine Ligand 1; SCYC1; LTN; ATAC; Lymphotactin; SCM-1a; SCM-1; LPTN; Small Inducible Cytokine Subfamily C, Member 1 (Lymphotactin); Chemokine (C Motif) Ligand 1; Small-Inducible Cytokine C1; XC Chemokine Ligand 1; C Motif Chemokine 1; Cytokine SCM-1; SCM-1-Alpha; Lymphotaxin; Single Cysteine Motif 1a; SCM1A; SCM1
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AA Sequence
VGTEVLEESSCVNLQTQRLPVQKIKTYIIWEGAMRAVIFVTKRGLKICADPEAKWVKAAIKTVDGRASTRKNMAETVPTGAQRSTSTAITLTG
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Predicted Molecular Mass
10.1 kDa
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Molecular Weight
Approximately 10 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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