CD200R1 Protein, Human (Biotinylated, HEK293, His-Avi)

CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein, thereby limiting inflammation by inhibiting TNF-α, interferons, and iNOS. CD200R1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD200R1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

CD200R1 is an inhibitory receptor that acts as a key regulator by binding to the CD200/OX2 cell surface glycoprotein. Its regulatory role extends to limiting inflammation in response to specific stimuli by inhibiting pro-inflammatory molecules including TNF-α, interferons, and inducible nitric oxide synthase (iNOS). CD200R1 exhibits comparable affinity and kinetics when binding to the human herpesvirus 8 K14 viral CD200 homolog. The interaction between CD200 and CD200R1 is facilitated by their respective N-terminal Ig-like domains. In addition, CD200R1 binds to the human herpesvirus 8 vOX2 protein, further extending its multifunctional interactions in cellular processes.

Immobilized Biotinylated Human CD200 R1 at 1 μg/mL (100μL/Well) on the plate. Dose response curve for Human CD200 with the EC₅₀ of 19.7 ng/mL determined by ELISA.

Human

HEK293

C-Avi;C-8*His

Q8TD46-4 (A27-L266)

131450  [NCBI]

Partial

Biotin

AAQPNNSLMLQTSKENHALASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKL

52-70 kDa

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.