1. GPCR/G Protein
  2. CaSR
  3. Calcium-Sensing Receptor Antagonists I

Calcium-Sensing Receptor Antagonists I 

Cat. No.: HY-50713 Purity: 99.02%
Handling Instructions

Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors.

For research use only. We do not sell to patients.

Calcium-Sensing Receptor Antagonists I Chemical Structure

Calcium-Sensing Receptor Antagonists I Chemical Structure

CAS No. : 478963-79-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 338 In-stock
Estimated Time of Arrival: December 31
10 mg USD 307 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1208 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. IC50 value: Target: CaSR Calcium-Sensing Receptor Antagonists I is useful for osteoporosis and other bone conditions

Molecular Weight

360.45

Formula

C₂₃H₂₄N₂O₂

CAS No.

478963-79-0

SMILES

C#CCOC1=CC2=C(N(C(N=C2C3=CC=C(C(C)C)C=C3)=O)C(C)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (277.43 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7743 mL 13.8715 mL 27.7431 mL
5 mM 0.5549 mL 2.7743 mL 5.5486 mL
10 mM 0.2774 mL 1.3872 mL 2.7743 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (9.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (9.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product name:
Calcium-Sensing Receptor Antagonists I
Cat. No.:
HY-50713
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