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Mitoquinone mesylate

(Synonyms: MitoQ mesylate; MitoQ10 mesylate)
138 Cited Publications
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Based on 138 publication(s) in Google Scholar

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage.

For research use only. We do not sell to patients.

  • Purity: 98.50%
  • CAS No.: 845959-50-4
  • Formula: C38H47O7PS
  • Molecular Weight:678.81
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Mitoquinone mesylate Chemical Structure
    Mitoquinone mesylate Chemical Structure
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
CAS No.: 845959-50-4
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  • Mitoquinone mesylate Chemical Structure
    Mitoquinone mesylate Chemical Structure
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    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     The total reactive oxygen species (ROS) was determined in heart tissue at 6 h post-reperfusion in the mitoquinone mesylate (MitoQ) (10 mg/kg 30 min prior to surgery and 2 h after reperfusion.)-treated and untreated MIRI group and sham group in WT mice and MAVS-KO mice. The expression levels of mitochondrial reactive oxygen species (mitoROS) were determined in heart tissue at 6 h post-reperfusion in the MitoQ-treated and untreated MIRI group and the sham group in WT mice and MAVS-KO mice.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 8;16(1):4292. [Abstract]

    Customer Validation
     Graph showing the relative proliferation of WT or Ant2−/− CD8+ T cells treated with the indicated concentrations of MitoQ (0-700 nM, 72 h). Relative proliferation was assessed by calculating the ratio of each treated sample’s P. index to the average P. index of the corresponding untreated control (WT or Ant2−/−)

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     Lysine-63 residues (K63)-type ubiquitination of MAVS in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     K63-type ubiquitination of RIG-I in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     Phosphorylation of JNK in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Sep;26(9):1545-1557. [Abstract]

    Customer Validation
     Cells were pretreated with Mito-Q (2 μM, 2 h); the levels of mito-ROS and lipid ROS are indicated.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Sep;26(9):1545-1557. [Abstract]

    Customer Validation
     Cells were pretreated with Mito-Q (2 μM, 2 h), the peroxidase activity of cyt.c was indicated.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jul 24;14(1):4456. [Abstract]

    Customer Validation
     Mitoquinone mesylate (Mito-Q, 5 mg/kg; i.p.; once daily for 3 days; mice) alleviates thioacetamide (TAA) (50 mg/kg; i.p.; once daily for 3 days)-induced hepatocyte necrosis.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2023 Apr 15:465:116452. [Abstract]

    Customer Validation
     Mitoquinone mesylate (MitoQ; 4 mg/kg; i.p.; pretreated for 1 h) alleviates APAP (Acetaminophen)-induced hepatic necrosis in mice.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2023 Feb:86:105487. [Abstract]

    Customer Validation
     Mitoquinone mesylate activates p62-Nrf2 signaling pathway in TP-treated H9c2 cells. H9c2 cells pretreates with 500 nM Mitoquinone mesylate for 4 h are exposed to 80 nM TP for 24 h.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2020 Dec 17;S1550-4131(20)30656-2. [Abstract]

    Customer Validation
     Effect of TRL and MitoQ (100 nM) on HIF1α and PDK1 protein levels in WT1 cells.

  • Mitoquinone mesylate