Copy Link Print Information

Mitoquinone mesylate

(Synonyms: MitoQ mesylate; MitoQ10 mesylate)
147 Cited Publications
고객리뷰

Based on 147 publication(s) in Google Scholar

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity : 98.50%
  • CAS No.: 845959-50-4
  • 화학식: C38H47O7PS
  • 분자량:678.81
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Mitoquinone mesylate Chemical Structure
    Mitoquinone mesylate Chemical Structure
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
  • Experimental Validation Results for Mitoquinone mesylate
CAS No.: 845959-50-4
사이즈
가격
재고
수량
Amount: USD 0.00
Please select quantity
or
or

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • 용액&용해도
  • Protocol
  • 순도&문서
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Mitoquinone mesylate

More
Customer Validation & Images
WBFlow CytometryCell Imaging/StainingCell Proliferation/Viability AssayIFIn Vivo Efficacy StudyRT-PCRIHC
  • Cell Proliferation/Viability Assay
  • IF
  • Flow Cytometry
  • Cell Imaging/Staining
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • Cell Imaging/Staining
  • RT-PCR
  • Cell Imaging/Staining
  • IF
  • Cell Proliferation/Viability Assay
  • WB
  • WB
  • WB
  • In Vivo Efficacy Study
  • IF
  • RT-PCR
  • Flow Cytometry
  • WB
  • IHC
  • IF
  • WB
  • WB

Keywords

MOQ
Minimum order quantity
100 mg

견적 받기 해외재고보유

Other size
견적 받기
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress 로그인
Register
Sign in to MedChemExpress
회원가입

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Mitoquinone mesylate Chemical Structure
    Mitoquinone mesylate Chemical Structure
    1/16
  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     The proliferation of HEY and OVCAR3 cells after 10 μM Rucaparib alone or in combination with 500 nM Mitoquinone mesylate (MitoQ) treatment for 48 h. The viable cell numbers were measured using flow cytometry by propidium iodide staining.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     Immunofluorescence staining of HIF1α and quantification in HEY cells after 10 μM PARP inhibitors (Rucaparib or Olaparib) alone or in combination with 500 nM Mitoquinone mesylate (MitoQ) treatment for 48 h. Scale bar: 50 μm. The results showed that scavenging of mtROS by MitoQ effectively blocked PARP inhibition-induced upregulation of HIF1α.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     Flow cytometric analysis of HIF1α expression quantity in HEY, OVCAR3, A2780, OV6314622 and SKOV3 cells after 10 μM PARP inhibitors (Rucaparib or Olaparib) alone or in combination with 500 nM Mitoquinone mesylate (MitoQ) treatment for 48 h. The results showed that scavenging of mtROS by MitoQ effectively blocked PARP inhibition-induced upregulation of HIF1α.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     SA-β-gal staining in HEY and OVCAR3 cells after 10 μM PARP inhibitors (Rucaparib or Olaparib) alone or in combination with 500 nM Mitoquinone mesylate (MitoQ) treatment for 48 h. Scale bar: 100 μm. The results showed that MitoQ led to a significant reduction of the senescence-like cells.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     OVCAR3 cells were subcutaneously transplanted in NCG mice. Mice were randomized into four treatment groups: vehicle (DMSO, n = 5), 2 mg/kg Mitoquinone mesylate (MitoQ) alone (n = 5) (given every other day by oral gavage for a total of 8 doses), 20 mg/kg Rucaparib alone (n = 5) (given daily by intraperitoneal injection for 15 days) or 20 mg/kg Rucaparib plus 2 mg/kg MitoQ (n = 5). Growth curves of tumors in mice. Tumor volumes were measured every day. Image of tumors and tumor weights in mice. The results showed that the combination of Rucaparib and MitoQ further inhibited tumor growth in NCG mice bearing tumor xenografts.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun:93:104158. [Abstract]

    Customer Validation
     Mitoquinone mesylate (MitoQ; 2 mg/kg; oral gavage; once every other day for a total of 8 doses) abolished the increase in lactate (a marker of glycolysis) production in NCG mice bearing tumor xenografts.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Oct 25. [Abstract]

    Customer Validation
     Representative images of JC-1 staining and quantification of its aggregates/monomers (%) in different groups of HK-2 cells. Mitochondrial stress assays showed that ulk1 deletion caused membrane depolarization, evidenced by a reduced JC-1 ratio, while Mitoquinone mesylate (MitoQ, 5 μM; 24 h) treatment restored mitochondrial potential, indicating that oxidative stress plays a key role in ulk1-KO-induced dysfunction.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Oct 25. [Abstract]

    Customer Validation
     TMLHE mRNA expression levels in different group of HK-2 cells. Tmlhe mRNA levels, decreased in HG-treated ulk1-KO TECs, were restored with Mitoquinone mesylate (MitoQ, 5 μM; 24 h), suggesting that impaired mitochondrial quality control underlies TMLHE downregulation.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     The total reactive oxygen species (ROS) was determined in heart tissue at 6 h post-reperfusion in the Mitoquinone mesylate (MitoQ) (10 mg/kg 30 min prior to surgery and 2 h after reperfusion.)-treated and untreated MIRI group and sham group in WT mice and MAVS-KO mice. The expression levels of mitochondrial reactive oxygen species (mitoROS) were determined in heart tissue at 6 h post-reperfusion in the MitoQ-treated and untreated MIRI group and the sham group in WT mice and MAVS-KO mice.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 12;16(1):7483. [Abstract]

    Customer Validation
     Representative HE staining and IF images of PTGS2 and DHODH with or without BQR and Mitoquinone mesylate (MitoQ, 5 mg/kg; i.p.; single dose) (Con:n = 4, Cis:n = 8). The results showed that pretreatment with mitoQ before AKI induction mitigated ferroptosis and ameliorated renal injury.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 8;16(1):4292. [Abstract]

    Customer Validation
     Graph showing the relative proliferation of WT or Ant2−/− CD8+ T cells treated with the indicated concentrations of Mitoquinone mesylate (MitoQ, 600-700 nM, 72 h). Relative proliferation was assessed by calculating the ratio of each treated sample’s P. index to the average P. index of the corresponding untreated control (WT or Ant2−/−)

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     Lysine-63 residues (K63)-type ubiquitination of MAVS in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     K63-type ubiquitination of RIG-I in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 2;16(1):5101. [Abstract]

    Customer Validation
     Phosphorylation of JNK in WT mice treated with or without Mitoquinone mesylate (MitoQ, 10 mg/kg; i.p.; twice daily) at 6 h post-reperfusion was determined by co-immunoprecipitation assay.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep:85:103715. [Abstract]

    Customer Validation
     Assessment of core body temperature in 10-week-old Atf4WT and Atf4AKO mice injected with Mitoquinone mesylate (MitoQ, 5 mg/kg; i.p.) during cold exposure (5 °C) (n = 4 per group). The results showed that although Atf4AKO mice treated with MitoQ exhibited a lower core body temperature in response to cold exposure, the drop was less pronounced and recovery occurred more rapidly—within approximately 24 h—compared to the untreated condition.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb:79:103454. [Abstract]

    Customer Validation
     Representative confocal images were immunostained for BRPnc82 in 15d fly brains of elav;tubulin-gal80ts/+ and elav;tubulin-gal80ts/blw RNAi with or without 14 h 1 mM Mitoquinone mesylate (MitoQ) supplementation; Quantification of BRPnc82 intensity within the central brain region was normalized to control. Scale bar: 50 um. Quantification of BRPnc82 intensity in 30d wildtype fly brains with or without mitoQ supplementation was performed. The results showed that MitoQ supplementation effectively reduced BRP protein levels in both aging flies (30d) as well as 15d neuronal blw KD fly brains relative to controls.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep:85:103715. [Abstract]

    Customer Validation
     Quantitative RT-PCR analysis of M1 macrophage markers (iNos and Itgax) and pro-inflammatory cytokines (Il1b, Tnfa, and Il6) in iWAT from 10-week-old Atf4WT and Atf4AKO mice exposed to cold (5 °C) for 3 days with or without injection of Mitoquinone mesylate (MitoQ, 5 mg/kg; i.p.). The results showed that MitoQ significantly reduced the expression of iNos and Itgax and Il1b, Tnfα, and Il6, which were upregulated by depletion of ATF4.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Sep;26(9):1545-1557. [Abstract]

    Customer Validation
     Cells were pretreated with Mitoquinone mesylat (Mito-Q, 2 μM, 2 h); the levels of mito-ROS and lipid ROS are indicated.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Sep;26(9):1545-1557. [Abstract]

    Customer Validation
     Cells were pretreated with Mitoquinone mesylat (Mito-Q, 2 μM, 2 h), the peroxidase activity of cyt.c was indicated.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jul 24;14(1):4456. [Abstract]

    Customer Validation
     Mitoquinone mesylate (Mito-Q, 5 mg/kg; i.p.; once daily for 3 days; mice) alleviates thioacetamide (TAA) (50 mg/kg; i.p.; once daily for 3 days)-induced hepatocyte necrosis.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2023 Apr 15:465:116452. [Abstract]

    Customer Validation
     Mitoquinone mesylate (MitoQ; 4 mg/kg; i.p.; pretreated for 1 h) alleviates APAP (Acetaminophen)-induced hepatic necrosis in mice.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2023 Feb:86:105487. [Abstract]

    Customer Validation
     Mitoquinone mesylate activates p62-Nrf2 signaling pathway in TP-treated H9c2 cells. H9c2 cells pretreates with 500 nM Mitoquinone mesylate for 4 h are exposed to 80 nM TP for 24 h.

  • 1/16

    Mitoquinone mesylate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Mar 2;33(3):547-564.e7. [Abstract]

    Customer Validation
     Effect of TRL and Mitoquinone mesylat (MitoQ, 100 nM) on HIF1α and PDK1 protein levels in WT1 cells.

  • Mitoquinone mesylate