FcRH5/FcRL5 Protein, Human (HEK293, His)

FcRH5/FcRL5 protein potentially plays a role in fertilization, engaging in intricate molecular pathways by interacting with signaling molecules such as PTPN6, PTPN11, SYK, and ZAP70. Its involvement in reproductive processes adds to its significance, and further exploration is needed to uncover its precise functions and molecular connections in the complex events of fertilization. FcRH5/FcRL5 Protein, Human (HEK293, His) is the recombinant human-derived FcRH5/FcRL5 protein, expressed by HEK293 , with C-His labeled tag.

The FcRH5/FcRL5 protein is suggested to potentially play a role in the complex process of fertilization, implicating its involvement in critical events related to reproductive biology. Furthermore, FcRH5/FcRL5 is known to interact with key signaling molecules, including PTPN6, PTPN11, SYK, and ZAP70, emphasizing its potential engagement in intricate molecular pathways associated with signal transduction. The interactions with these signaling proteins suggest that FcRH5/FcRL5 may participate in regulatory networks influencing cellular responses, and its role in fertilization adds to its significance in reproductive processes. The specific mechanisms by which FcRH5/FcRL5 contributes to fertilization and its interactions with signaling partners remain areas of interest, underscoring the need for further exploration to unveil its exact functions and molecular connections in reproductive biology.

1.Immobilized Human FcRH5, His Tag at 0.5 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-FcRH5 Antibody, hFc Tag with the EC₅₀ of 3.6-21.5 ng/mL determined by ELISA.
2.Immobilized Human FcRH5, His Tag at 1 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-FcRH5 Antibody, hFc Tag with the EC₅₀ of 3.5 ng/mL determined by ELISA.
3.Measured by its ability to bind human IgG1. The Kd for this effect is 8.246 nM. (ELISA)
4.Loaded Cevostamab (HY-P99601) on AHC2 biosensor, can bind FcRH5/FcRL5 Protein, Human (HEK293, His) with an affinity constant of 1.605×10^-11 M as determined in BLI assay.

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  Loaded Cevostamab (HY-P99601) on AHC2 biosensor, can bind FcRH5/FcRL5 Protein, Human (HEK293, His) with an affinity constant of 1.605E-11 M as determined in BLI assay.

Human

HEK293

C-His

Q96RD9-1 (Q16-G851)

83416  [NCBI]

Extracellular Domain

QFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPHSIISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEDAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSITVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATG

95-140 kDa.

> 95%, as determined by Bis-Tris PAGE.

Lyophilized powder

1.Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
2.Lyophilized from a 0.22 μm filtered solution of PBS, 8% trehalose, pH 7.4.
3.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
Please refer to the lot-specific COA for specific buffer information.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.