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Cevostamab

(Synonyms: BFCR 4350A; RG 6160; RO 7187797)
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Based on 1 Customer Validation

Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized IgG1-based BsAb that targets membrane-proximal extracellular domain of FcRH5 on multiple myeloma (MM) cells as well as CD3 on T cells. Moreover, Cevostamab facilitates efficient synapse formation, improves killing activity of T cells against MM tumor cells.

For research use only. We do not sell to patients.

  • Purity : ≥99%
  • CAS No.: 2249888-53-5
  • Molecular Weight:146.19 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cevostamab
  • Experimental Validation Results for Cevostamab
  • Experimental Validation Results for Cevostamab
  • Experimental Validation Results for Cevostamab
  • Experimental Validation Results for Cevostamab
  • Cevostamab Chemical Structure
    Cevostamab Chemical Structure
CAS No.: 2249888-53-5
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Cevostamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Cevostamab on AHC2 biosensor, can bind FcRH5/FcRL5 Protein, Human (HEK293, His, HY-P700302) with an affinity constant of 1.605E-11 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 HepG2 cells labeling FcRH5 with Cevostamab (HY-P99601, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • 1/16

    Loaded Cevostamab on AHC2 biosensor, can bind CD3 epsilon Protein, Human (HEK293, His, HY-P70506) with an affinity constant of 3.265E-11 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling CD3 with Cevostamab (HY-P99601, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Cevostamab Chemical Structure
    1/16
  • Cevostamab
  • Loaded Cevostamab on AHC2 biosensor, can bind FcRH5/FcRL5 Protein, Human (HEK293, His, HY-P700302) with an affinity constant of 1.605E-11 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 HepG2 cells labeling FcRH5 with Cevostamab (HY-P99601, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • Loaded Cevostamab on AHC2 biosensor, can bind CD3 epsilon Protein, Human (HEK293, His, HY-P70506) with an affinity constant of 3.265E-11 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 Jurkat cells labeling CD3 with Cevostamab (HY-P99601, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).