CSP-2503
CSP-2503 is a potent and selective 5-HT1A receptor agonist , with an EC50 of 0.15 μM and a Ki of 4.1 nM. CSP-2503 exhibits excellent selectivity over α1-adrenoceptors (Ki > 1000 nM), 5-HT4 receptors, and benzodiazepine receptors. CSP-2503 inhibits cAMP increase in vitro and exhibits anxiolytic activity in vivo. CSP-2503 can be used for the research of anxiety-related disorders.
For research use only. We do not sell to patients.
- CAS No.: 581813-10-7
- Formula: C22H26N4O2
- Molecular Weight:378.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1A Receptor 0.15 μM (EC50) |
5-HT1A Receptor 4.1 nM (Ki) |
5-HT2A Receptor 13.5 nM (Ki) |
5-HT3 Receptor 8.9 nM (Ki) |
5-HT4 Receptor >10000 nM (Ki) |
5-HT7 Receptor 100.9 nM (Ki) |
α1-adrenergic receptor >1000 nM (Ki) |
serotonin transporter 976.3 nM (Ki) |
benzodiazepine receptor >10000 nM (Ki) |
Dopamine D2 receptor 192.1 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| HeLa | EC50 |
0.15 μM
Compound: 9 (S)
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Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells
Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells
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[PMID: 15801844] |
CSP-2503 (2.5-20 mg/kg; s.c.; single dose) acts as a somatodendritic 5-HT1A receptor agonist in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:10 mg/kg
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Administration:s.c.; single dose
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Result:Increased time spent in the lit area to 155.4 seconds compared to 83 seconds in vehicle-treated mice.
Increased time spent in the lit area by 87.2%.
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Animal Model:Mice hypothermia model[1]
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Dosage:2.5, 5, 10, 20 mg/kg
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Administration:s.c.; single dose
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Result:Induced a dose-related decrease in rectal temperature.
Decreased the 5-HIAA/5-HT ratio in mouse hypothalamus.
Chemical Information
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CAS No. 581813-10-7
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Molecular Weight 378.48
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Formula C22H26N4O2
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SMILES
C(N1CCN(C=2C3=C(C=CC2)C=CC=C3)CC1)N4C(=O)[C@]5(N(C(=O)C4)CCC5)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CSP-2503 Related Classifications
HY-180372 Related Classifications
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- CSP-2503
- 581813-10-7
- CSP2503
- CSP 2503
- 5-HT Receptor
- Adrenergic Receptor
- GABA Receptor
- Serotonin Transporter
- Dopamine Receptor
- Mice
- serotonin receptor subtypes
- postsynaptic sites
- 5-HT1A receptor
- 5-HT?A receptors
- somatodendritic sites
- dopamine D? receptors
- α?-adrenergic receptors
- benzodiazepine receptors
- forskolin-induced cAMP increase
- Anxiety model
- hypothalamic 5-HIAA/5-HT ratio
- 5-HT? receptors
- anxiolytic properties
- serotonin transporter
- anxiety-related disorders
- 5-HT neuronal activity modulation model
- Somatodendritic 5-HT?A receptor activation model
- Inhibitor
- inhibitor
- inhibit