581813-10-7
Chemical Structure
CSP-2503
- CAS No.: 581813-10-7
- Formula:C22H26N4O2
- Molecular Weight:378.48
IUPAC Name: (S)-2-((4-(naphthalen-1-yl)piperazin-1-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
InChIKey: CTZWGZSINBFHFD-FQEVSTJZSA-N
SMILES: C(N1CCN(C=2C3=C(C=CC2)C=CC=C3)CC1)N4C(=O)[C@]5(N(C(=O)C4)CCC5)[H]
Biological Activity: CSP-2503 is a potent and selective 5-HT1A receptor agonist , with an EC50 of 0.15 μM and a Ki of 4.1 nM. CSP-2503 exhibits excellent selectivity over α1-adrenoceptors (Ki > 1000 nM), 5-HT4 receptors, and benzodiazepine receptors. CSP-2503 inhibits cAMP increase in vitro and exhibits anxiolytic activity in vivo. CSP-2503 can be used for the research of anxiety-related disorders[1].
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CSP-2503 | CSP-2503 is a potent and selective 5-HT1A receptor agonist , with an EC50 of 0.15 μM and a Ki of 4.1 nM. CSP-2503 exhibits excellent selectivity over α1-adrenoceptors (Ki > 1000 nM), 5-HT4 receptors, and benzodiazepine receptors. CSP-2503 inhibits cAMP increase in vitro and exhibits anxiolytic activity in vivo. CSP-2503 can be used for the research of anxiety-related disorders. | |||||||||||||||||||||
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Keywords
