Amitriptyline-d3 hydrochloride

Name: Amitriptyline-d3 hydrochloride
Brand: MedChemExpress
SKU: HY-135096
Rating: 4.5 (1 reviews)

Cat. No.: HY-135096 Purity: 99.46%: FAQs
Data Sheet SDS COA Handling Instructions

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Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

For research use only. We do not sell to patients.

Amitriptyline-d3 hydrochloride Chemical Structure

CAS No. : 342611-00-1

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Amitriptyline-d3 hydrochloride:

Amitriptyline hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.88

Formula

C₂₀H₂₁D₃ClN

CAS No.

342611-00-1

Appearance

Solid

Color

White to off-white

SMILES

[2H]C(N(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13)([2H])[2H].[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (157.79 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1558 mL	15.7788 mL	31.5577 mL
5 mM	0.6312 mL	3.1558 mL	6.3115 mL
10 mM	0.3156 mL	1.5779 mL	3.1558 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.46%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (108 KB) RP-HPLC (72 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.;Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and C [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.1558 mL	15.7788 mL	31.5577 mL	78.8942 mL
	5 mM	0.6312 mL	3.1558 mL	6.3115 mL	15.7788 mL
	10 mM	0.3156 mL	1.5779 mL	3.1558 mL	7.8894 mL
	15 mM	0.2104 mL	1.0519 mL	2.1038 mL	5.2596 mL
	20 mM	0.1578 mL	0.7889 mL	1.5779 mL	3.9447 mL
	25 mM	0.1262 mL	0.6312 mL	1.2623 mL	3.1558 mL
	30 mM	0.1052 mL	0.5260 mL	1.0519 mL	2.6298 mL
	40 mM	0.0789 mL	0.3945 mL	0.7889 mL	1.9724 mL
	50 mM	0.0631 mL	0.3156 mL	0.6312 mL	1.5779 mL
	60 mM	0.0526 mL	0.2630 mL	0.5260 mL	1.3149 mL
	80 mM	0.0394 mL	0.1972 mL	0.3945 mL	0.9862 mL
	100 mM	0.0316 mL	0.1578 mL	0.3156 mL	0.7889 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.