2. GPCR/G Protein
    Neuronal Signaling
  3. mAChR
  4. Xanomeline

Xanomeline  (Synonyms: LY-246708)

Cat. No.: HY-105182 Purity: 99.32%
COA Handling Instructions

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

For research use only. We do not sell to patients.

Xanomeline Chemical Structure

Xanomeline Chemical Structure

CAS No. : 131986-45-3

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
 USD 66 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
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50 mg USD 320 In-stock
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100 mg USD 510 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].

IC50 & Target

M1/M4[1][2]
In Vitro

Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Cebus apella monkeys
Dosage: 0.5~3 mg/kg
Administration: S.c.; 1~3 hours
Result: Induced salivation and vomiting in some monkeys.
Clinical Trial
Molecular Weight

281.42

Appearance

Solid

Formula

C14H23N3OS
CAS No.
SMILES

CCCCCCOC1=NSN=C1C2=CCCN(C)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (177.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5534 mL 17.7670 mL 35.5341 mL
5 mM 0.7107 mL 3.5534 mL 7.1068 mL
10 mM 0.3553 mL 1.7767 mL 3.5534 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.88 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Xanomeline131986-45-3LY-246708LY246708LY 246708mAChRMuscarinic acetylcholine receptoreffectiveselectivemuscarinicneuronalexcitabilityneurologicaldisordersschizophreniaInhibitorinhibitorinhibit

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