1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Xanomeline

Xanomeline (Synonyms: LY-246708)

Cat. No.: HY-105182
Handling Instructions

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

For research use only. We do not sell to patients.

Xanomeline Chemical Structure

Xanomeline Chemical Structure

CAS No. : 131986-45-3

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Description

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].

IC50 & Target

M1/M4[1][2]

In Vitro

Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (>1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Cebus apella monkeys
Dosage: 0.5~3 mg/kg
Administration: S.c.; 1~3 hours
Result: Induced salivation and vomiting in some monkeys.
Molecular Weight

281.42

Formula

C₁₄H₂₃N₃OS

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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