PKCγ
PKCγ is a neuronal conventional protein kinase C isoform that links Ca2+-dependent signaling to cerebellar Purkinje cell excitability, motor coordination, and hippocampal synaptic plasticity[1][2]. Mechanistically, PKCγ activation suppresses dendritic BK channels in Purkinje cells, while PKCγ loss modifies hippocampal long-term potentiation and disrupts cerebellar climbing-fiber synapse elimination[1][2][3]. In disease models, PKCγ knockout mice show reduced neuropathic pain after nerve injury, and PRKCG mutations causing spinocerebellar ataxia type 14 increase kinase activity and alter membrane targeting[4][5]. Compared with PKCα and PKCβ, PKCγ has a more neuron-focused experimental profile, making isoform distinction essential when designing CNS signaling, ataxia, pain, or synaptic plasticity studies[2][3][5]. For experimental applications, broad PKC inhibitors such as GF109203X can inhibit PKCγ but should be interpreted as non-isoform-selective tools unless paired with genetic or isoform-specific validation[6].
References:
- [1]. Watanave M, et al. Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2113336119. [Content Brief]
- [2]. Abeliovich A, et al. Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell. 1993 Dec 31;75(7):1253-62. [Content Brief]
- [3]. Kano M, et al. Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Cell. 1995 Dec 29;83(7):1223-31. [Content Brief]
- [4]. Malmberg AB, et al. Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science. 1997 Oct 10;278(5336):279-83. [Content Brief]
- [5]. Verbeek DS, et al. Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting. Brain. 2005 Feb;128(Pt 2):436-42. [Content Brief]
- [6]. Toullec D, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C[J]. Journal of biological chemistry, 1991, 266(24): 15771-15781.
-
PKCγ Related Products (29)
Related Products (29)
-
Antibodies (1)
- 1
- 2
-
βGlcCer
0 ImagesCat. No.: HY-152940CAS No.: 887907-50-8Synonyms: C24:1 β-glucosylceramideβGlcCer is a glycosphingolipid. βGlcCer directly increases the development and PKCα and PKCδ activation in mouse bone marrow-derived DCs (BMDCs). β-GlcCer accumulating in Gaucher disease activates microglia through macrophage-inducible C-type lectin (Mincle) to induce phagocytosis of living neurons, which exacerbates Gaucher symptoms.
-
Ro 31-8220
0 ImagesCat. No.: HY-13866ACAS No.: 125314-64-9Synonyms: Bisindolylmaleimide IXRo 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.
-
PF-04577806
0 ImagesCat. No.: HY-139467CAS No.: 1072100-81-2
-
1,2-Dipalmitoyl-sn-glycerol (Standard)
0 ImagesCat. No.: HY-W010736RCAS No.: 30334-71-51,2-Dipalmitoyl-sn-glycerol (Standard) is the analytical standard of 1,2-Dipalmitoyl-sn-glycerol (HY-W010736). This product is intended for research and analytical applications. 1,2-Dipalmitoyl-sn-glycerol is a diacylglycerol that activates PKC. 1,2-Dipalmitoyl-sn-glycerol promotes GLUT4 translocation to the cell surface and recruitment to the plasma membrane of adipocytes. 1,2-Dipalmitoyl-sn-glycerol can be used in research on type 2 diabetes.
-
Dioleyl phosphatidylserine
0 ImagesCat. No.: HY-141613ACAS No.: 6811-55-8Dioleyl phosphatidylserine is a phospholipid that can be used to form the cochlea. Dioleyl phosphatidylserine (100 μM) can activate PKC-γ under Ca2+ concentrations < 0.5 μM.
-
Bisindolylmaleimide VIII
0 ImagesCat. No.: HY-129624CAS No.: 125313-65-7Synonyms: Ro 31-7549; Bis VIIIBisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
-
Balanol
0 ImagesCat. No.: HY-121197CAS No.: 63590-19-2Synonyms: Ophiocordin; AzepinostatinBalanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides.
- 1
- 2
