887907-50-8
Chemical Structure
βGlcCer
Synonym(s): C24:1 β-glucosylceramide
- CAS No.: 887907-50-8
- Formula:C48H91NO8
- Molecular Weight:810.26
IUPAC Name: (Z)-N-((2S,3R,E)-3-hydroxy-1-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadec-4-en-2-yl)tetracos-15-enamide
InChIKey: WBOZIXHPUPAOIA-JZZPSRGZSA-N
SMILES: O(C[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Biological Activity: βGlcCer is a glycosphingolipid. βGlcCer directly increases the development and PKCα and PKCδ activation in mouse bone marrow-derived DCs (BMDCs)[2]. β-GlcCer accumulating in Gaucher disease activates microglia through macrophage-inducible C-type lectin (Mincle) to induce phagocytosis of living neurons, which exacerbates Gaucher symptoms[3].
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βGlcCer | βGlcCer is a glycosphingolipid. βGlcCer directly increases the development and PKCα and PKCδ activation in mouse bone marrow-derived DCs (BMDCs). β-GlcCer accumulating in Gaucher disease activates microglia through macrophage-inducible C-type lectin (Mincle) to induce phagocytosis of living neurons, which exacerbates Gaucher symptoms. | |||||||||||||||||||||
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- [2]. Lajiness JD, Amarsaikhan N, Tat K, Tsoggerel A, Cook-Mills JM. β-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells. J Immunol. 2022;209(10):1837-1850. [Content Brief]
- [3]. Shimizu T, Schutt CR, Izumi Y, et al. Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease. Immunity. 2023;56(2):307-319.e8. [Content Brief]
Keywords
