63590-19-2
Chemical Structure
Balanol
Synonym(s): Ophiocordin; Azepinostatin
- CAS No.: 63590-19-2
- Formula:C28H26N2O10
- Molecular Weight:550.51
IUPAC Name: 2-(2,6-dihydroxy-4-((((3R,4R)-3-(4-hydroxybenzamido)azepan-4-yl)oxy)carbonyl)benzoyl)-3-hydroxybenzoic acid
InChIKey: XYUFCXJZFZPEJD-XMSQKQJNSA-N
SMILES: O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O
Biological Activity: Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides[1][2].
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Balanol | Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides. | |||||||||||||||||||||
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- [1]. Gustafsson AB, et al. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug;56(2):377-82. [Content Brief]
- [2]. Kulanthaivel P, et al. Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. Journal of the American Chemical Society, 1993, 115(14): 6452-6453.
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