1. Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. PKC
    Apoptosis
  3. HBDDE

HBDDE 

Cat. No.: HY-131305
Handling Instructions

HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.

For research use only. We do not sell to patients.

HBDDE Chemical Structure

HBDDE Chemical Structure

CAS No. : 154675-18-0

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Description

HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].

IC50 & Target[1]

PKCα

43 μM (IC50)

PKCγ

50 μM (IC50)

In Vitro

HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Cerebellar granule cells
Concentration: 50 μM
Incubation Time: 5 hours
Result: Reduced cell viability significantly by ~70%.
Molecular Weight

338.31

Formula

C₁₆H₁₈O₈

CAS No.

154675-18-0

SMILES

OC1=CC(COC)=C(C2=C(C(O)=C(C=C2COC)O)O)C(O)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HBDDEPKCApoptosisProtein kinase CPKCαPKCγisoformselectiveapoptosiscell-permeableInhibitorinhibitorinhibit

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