78957-85-4
Chemical Structure
A-3 hydrochloride
- CAS No.: 78957-85-4
- Formula:C12H14Cl2N2O2S
- Molecular Weight:321.22
IUPAC Name: N-(2-aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride
InChIKey: VWAGIWCLJAQLAL-UHFFFAOYSA-N
SMILES: O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl
Biological Activity: A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].
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A-3 hydrochloride | 99.75% | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively. | ||||||||||||||||||||
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Keywords
