1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Aprindine hydrochloride

Aprindine hydrochloride 

Cat. No.: HY-A0236A
Handling Instructions

Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias treatment research.

For research use only. We do not sell to patients.

Aprindine hydrochloride Chemical Structure

Aprindine hydrochloride Chemical Structure

CAS No. : 33237-74-0

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Description

Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM[1]. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias treatment research[2].

In Vitro

Aprindine (3 μM) inhibits the delayed rectifier K+ current (IK) with little influence on the inward rectifier K+ current (IK1) or the Ca2+ current[2].
The muscarinic acetylcholine receptor-operated K+ current (IK.ACh) was activated by the extracellular application of carbachol (1 μM) or by the intracellular loading of GTPγS. Aprindine inhibits the carbachol- and GTPγS-induced IK.ACh with the IC50 values of 0.4 μM and 2.5 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.95

Formula

C₂₂H₃₁ClN₂

CAS No.
SMILES

CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AprindinePotassium ChannelKcsAInhibitorinhibitorinhibit

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Aprindine hydrochloride
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HY-A0236A
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