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Cat. No.: HY-138947

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KB-R7943

Name: KB-R7943
Brand: MedChemExpress
SKU: HY-138947
Price: 357.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.

For research use only. We do not sell to patients.

CAS No.: 182004-64-4
Formula: C₁₆H₁₇N₃O₃S
Molecular Weight:331.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

KB-R7943 Chemical Structure

CAS No.: 182004-64-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models^[1].

Chemical Information

CAS No. 182004-64-4
Molecular Weight 331.39
Formula C₁₆H₁₇N₃O₃S
SMILES

NC(SCCC1=CC=C(OCC2=CC=C([N+]([O-])=O)C=C2)C=C1)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Aging Cell

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription. [Abstract]

2022 May;21(5):e13593. PMID: 35353937
Br J Pharmacol

Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Nav 1.6 inhibition in microglia. [Abstract]

2021 Sep;178(17):3553-3569. PMID: 33886140
J Am Heart Assoc

Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling. [Abstract]

2022 Aug 2;11(15):e025328. PMID: 35904193
Am J Physiol Cell Physiol

PFOS-induced Sertoli cell injury through c-Jun N-terminal kinase (JNK) - a study by RNA-Seq. [Abstract]

2024 Aug 1;327(2):C291-C309. PMID: 38826136

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takahiro Kuramochi, et al. Discovery of N-(3-{4-[(3-fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4-ylacetamide as a potent and selective reverse NCX inhibitor. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1043-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KB-R7943

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KB-R7943

Publications Citing Use of MedChemExpress (MCE) KB-R7943

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Publications (4)

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