161374-55-6
161374-55-6
Chemical Structure
Heptamidine dimethanesulfonate
Synonym(s): SBi4211 dimethanesulfonate
- CAS No.: 161374-55-6
- Formula:C23H36N4O8S2
- Molecular Weight:560.68
IUPAC Name: 4,4'-(heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate
InChIKey: VJPVVWMWVOBCIC-UHFFFAOYSA-N
SMILES: N=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.CS(=O)(O)=O.CS(=O)(O)=O
Biological Activity: Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Heptamidine dimethanesulfonate | 99.12% | Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM). | ||||||||||||||||||||
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References
- [1]. McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. Epub 2012 Sep 25. [Content Brief]
- [2]. Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8(11):2528-37. [Content Brief]
