1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Neurotrophic Factors
  4. Neurotrophins/NGF
  5. Neurotrophin-3
  6. Neurotrophin-3 Protein, Human

Neurotrophin-3 Protein, Human

Cat. No.: HY-P70456
COA Handling Instructions

Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
2 μg $125 In-stock
Estimated Time of Arrival: December 31
10 μg $340 In-stock
Estimated Time of Arrival: December 31
50 μg $1020 In-stock
Estimated Time of Arrival: December 31
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250 μg   Get quote  

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Description

Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions[1].

Background

Neurotrophin‐3 (NT‐3), a trophic factor from the neurotrophin family, is widely expressed in the nervous system.
The physiological actions of NT‐3 are mediated by the activation of two membrane receptors: the low‐affinity receptor p75 and the high‐affinity receptor Trk. NT‐3 activates the TrkC receptor and binds with less affinity to TrkB and TrkA.
NT‐3 reduces cellular damage, improves neuronal regeneration in different models of lesions or neurodegeneration, and participates in synaptic reorganization, synapse formation, and neuronal plasticity[1].

Species

Human

Source

E. coli

Tag

Tag Free

Accession

P20783 (Y139-T257)

Gene ID

4908  [NCBI]

Synonyms
Neurotrophin-3; NT-3; HDNF; Nerve Growth Factor 2; NGF-2; Neurotrophic Factor; NTF3
AA Sequence

YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Molecular Weight

Approximately 14.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.2.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Documentation
References

Neurotrophin-3 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Neurotrophin-3 Protein, Human
Cat. No.:
HY-P70456
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