2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Neurotrophic Factors
  5. Neurotrophins/NGF
  6. Nerve Growth Factor-β (Beta-NGF)

Nerve Growth Factor-β (Beta-NGF)

Recombinant Protein Expression Service

Nerve Growth Factor-β (Beta-NGF)

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Nerve Growth Factor-β (Beta-NGF; NGF) is a basic protein of 118 amino acids which acts are a trophic factor for sensory and sympathetic neurons of the peripheral nervous system, and on cholinergic neurons of the anterior basal cerebrum[1]. NGF involves in the regulation of neuronal survival and differentiation. Elevated levels of NGF are associated with the risk of post-traumatic stress disorder (PTSD). The trauma response leads to methylation of DNA nucleotides responsible for NGF expression. NGF levels have shown increased sympathetic fiber density proportional to NGF messenger RNA (mRNA) levels. NGF is also a seminal plasma protein commonly found in mammals. For example, NGF acts as an ovulation stimulating factor in camels and has been shown to have luteinizing effects in bulls. NGF has a potential function in the female reproductive system. For example, NGF plays an important role in ovulation induction, LH release, ovulation, luteal development, progesterone (P4) production, vascularization of luteal body, and gonadotropin response. Application of NGF to cattle enhances steroid production, luteal formation and function by increasing LH release, and leads to increased mRNA expression of markers of pregnancy and development downstream. In addition, the potential luteinizing effect of NGF could help overcome the current problem of early embryo loss[2][3]. The similarity between human and bovine NGF protein sequence was 90.87%. Meanwhile, the similarity rate of human NGF with rat and mouse was 85.89% and 85.06%, respectively.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7660
    Beta-NGF Protein, Human (HEK293)

    rHuBeta-NGF; Beta-Nerve Growth Factor; Beta-NGF;

    		Human HEK293
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (HEK293) is produced by HEK293 cells (S122-R239), with tag free.
  • HY-P73316
    Beta-NGF Protein, Human (CHO)

    Beta-NGF; Beta-Nerve Growth Factor; NGF; NGFB

    		Human CHO
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (CHO) is produced by CHO cells (S122-R239), with tag free.
  • HY-P73317
    Beta-NGF Protein, Mouse (CHO)

    Beta-NGF; Beta-Nerve Growth Factor; NGF; NGFB

    		Mouse CHO
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (CHO) is produced by CHO cells (S122-G241), with tag free.
  • HY-P700018AF
    Animal-Free Beta-NGF Protein, Human (His)

    β-Nerve Growth Factor; NGF-β

    		Human E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.
  • HY-P7661
    Beta-NGF Protein, Mouse (120a.a)

    rMuBeta-NGF; Beta-nerve growth factor; Beta-NGF;

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (120a.a) is produced by E.coli (S122-G241), with tag free.
  • HY-P70530
    Beta-NGF Protein, Mouse (110a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (110a.a) is produced by E.coli (M130-R239), with tag free.
  • HY-P70449
    Beta-NGF Protein, Human (120a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Human E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (120a.a) is produced by E.coli (S122-A241), with tag free.
  • HY-P700162AF
    Animal-Free Beta-NGF Protein, Mouse (His)

    beta-NGF; beta-Nerve Growth Factor; NGF; NGFB

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Mouse (His) is produced by E.coli (S122-G241), with C-terminal His-tag.
  • HY-P70530A
    Beta-NGF Protein, Mouse (110a.a, His)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Mouse E. coli
    Beta-NGF Protein, vital for developing and maintaining the nervous systems, engages NTRK1 and NGFR receptors, initiating signaling cascades regulating neuronal processes. The NGF precursor, proNGF, acts as a ligand for the SORCS2-NGFR receptor, activating pathways that impact RAC1/2, actin cytoskeleton, and neuronal growth. In vitro, proNGF induces neuronal apoptosis. Beta-NGF inhibits platelet glycoprotein VI proteolysis, binds lysophosphatidylinositol and lysophosphatidylserine, influencing mast cell histamine release. Its homodimer interacts with NTRK1, NGFR, and SORCS2, and proNGF binds to SORT1-NGFR, leading to NGF endocytosis. These interactions highlight Beta-NGF's multifaceted roles in cellular responses. Beta-NGF Protein, Mouse (110a.a, His) is the recombinant mouse-derived Beta-NGF protein, expressed by E. coli, with N-6*His labeled tag. The total length of Beta-NGF Protein, Mouse (110a.a, His) is 110 a.a., with molecular weight of ~12.0 kDa.
  • HY-P72488
    pro-Beta-NGF Protein, Human (223a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Human E. coli
    Pro-Beta-NGF protein plays a crucial role in the development and maintenance of the nervous system by binding to NTRK1 and NGFR receptors. Immature NGF precursors act as ligands for the SORCS2-NGFR complex, triggering signaling pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. pro-Beta-NGF Protein, Human (223a.a) is the recombinant human-derived pro-Beta-NGF protein, expressed by E. coli , with tag free. The total length of pro-Beta-NGF Protein, Human (223a.a) is 223 a.a., with molecular weight of ~30 kDa.
Cat. No. Product Name Effect Purity