BDNF Protein, Mouse (R129A, R130A, HEK293, C-His)

The BDNF protein serves as a pivotal signaling molecule, activating cascades downstream of NTRK2 and playing diverse roles in neuronal development and function. During development, BDNF promotes the survival and differentiation of specific neuronal populations in both the peripheral and central nervous systems, influencing axonal growth, pathfinding, and the modulation of dendritic growth and morphology. It emerges as a major regulator of synaptic transmission and plasticity in various regions of the CNS, contributing to adaptive neuronal responses such as long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, and the homeostatic regulation of intrinsic neuronal excitability. This versatility underscores its integral role in shaping neuronal connectivity and function. Additionally, BDNF activates signaling cascades through the heterodimeric receptor formed by NGFR and SORCS2, further influencing synaptic plasticity and long-term depression. Notably, its interaction with NGFR and SORCS2 is implicated in promoting neuronal apoptosis and growth cone collapse, highlighting its multifaceted impact on neuronal physiology and development.