2070009-72-0
Chemical Structure
MMAE-d8
Synonym(s): Monomethyl auristatin E-d8;Deuterated labeled MMAE
- CAS No.: 2070009-72-0
- Formula:C39H59D8N5O7
- Molecular Weight:726.03
IUPAC Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N-methyl-3-(methyl-d3)-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide-2,3,4,4,4-d5
InChIKey: DASWEROEPLKSEI-CMHCZSPYSA-N
SMILES: O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Biological Activity: MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
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MMAE-d8 | 99.15% | MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor. | ||||||||||||||||||||
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Monomethyl auristatin E (GMP) | Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor. | |||||||||||||||||||||
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Monomethyl auristatin E (Standard) | 99.99% | Monomethyl auristatin E (MMAE) (Standard) is the analytical standard of Monomethyl auristatin E (HY-15162). This product is intended for research and analytical applications. Monomethyl auristatin E is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) against several different cancer types. | ||||||||||||||||||||
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Monomethyl auristatin E | 101.1% | Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. | ||||||||||||||||||||
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