790702-57-7
790702-57-7
Chemical Structure
NGI-1
Synonym(s): ML414
- CAS No.: 790702-57-7
- Formula:C17H22N4O3S2
- Molecular Weight:394.51
IUPAC Name: 5-(N,N-dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
InChIKey: QPKGRLIYJGBKJL-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=C(C)S1)C2=CC(S(=O)(N(C)C)=O)=CC=C2N3CCCC3
Biological Activity: NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B[1]. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability[2].
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NGI-1 | 99.97% | NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability. | ||||||||||||||||||||
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NGI-1 (Standard) | ≥98% | NGI-1 (Standard) is the analytical standard of NGI-1 (HY-117383). This product is intended for research and analytical applications. NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocKing the function of the OST catalytic subunits STT3A and STT3B. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability. | ||||||||||||||||||||
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References
- [1]. Zhu S, et al. Comprehensive Interactome Analysis Reveals that STT3B is Required for the N-Glycosylation of Lassa Virus Glycoprotein. J Virol. 2019 Sep 11. pii: JVI.01443-19. [Content Brief]
- [2]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030. [Content Brief]
