Cat. No.: HY-171007

IRF1-IN-2

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury.

For research use only. We do not sell to patients.

Purity: 99.83%
CAS No.: 708245-32-3
Formula: C₁₈H₂₀N₂O₄S
Molecular Weight:360.43

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

IRF1-IN-2 Chemical Structure

CAS No.: 708245-32-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PARP-1

GPX4

IL-1

Caspase-1

All Caspase Isoforms :

All PARP Isoforms :

All Interleukin Related Isoforms :

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

In Vitro

IRF1-IN-2 pretreatment (20 μM, 12 h) decreases the recruitment of IRF1 to the promoter of CASP1 in irradiated HaCaT cells (20 Gy)^[1].
IRF1-IN-2 (20 μM, 24 h) attenuates the NSP-10 plasmid transfection-induced IRF1 activation in HELF and WS1 cells^[1].
IRF1-IN-2 protects A375 cells against radiation (20 Gy)^[1].
IRF1-IN-2 inhibits cell death signaling pathways, including inhibition of cleavage for Caspase 1, GSDMD, IL-1 and PARP1, phosphorylation of TKB1, up-regulation of GPX4 and down-regulation of FACL4^[1].
IRF1-IN-2 maintains mitochondrial activity and ROS production in skin cells in the early stage after irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IRF1-IN-2 pretreatment (100 μg/d, s.c., one every other day before irradiation) has a potential protective effect in 35 Gy radiation-induced inflammatory skin injury mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Radiogenic skin injury mice (intraperitoneal injection of pentobarbital sodium (1%, 30 mg/kg), 35 Gy at the dose rate of 1000 cGy/min by a 6-MeV electron beam)^[1]
Dosage:

100 μg/d
Administration:

Subcutaneous injection (s.c.), one every other day before irradiation, pretreatment
Result:

Showed a significant reduction in acute skin inflammatory manifestations, such as erythema and exudation.
Showed protective effects on the function and structural integrity of radiation-induced lesions to the claws.

Chemical Information

CAS No. 708245-32-3
Appearance Solid
Molecular Weight 360.43
Formula C₁₈H₂₀N₂O₄S
Color White to off-white
SMILES

O=C(NC1=CC=C(S(=O)(N2CCCC2)=O)C=C1)C3=CC=CC=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Antioxidants (Basel)

Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor Cytotoxicity. [Abstract]

2026 Mar 25;15(4):413. PMID: 42072056

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (346.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7745 mL

13.8723 mL

27.7446 mL

5 mM

0.5549 mL

2.7745 mL

5.5489 mL

10 mM

0.2774 mL

1.3872 mL

2.7745 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21(8):856-872. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7745 mL	13.8723 mL	27.7446 mL	69.3616 mL
	5 mM	0.5549 mL	2.7745 mL	5.5489 mL	13.8723 mL
	10 mM	0.2774 mL	1.3872 mL	2.7745 mL	6.9362 mL
	15 mM	0.1850 mL	0.9248 mL	1.8496 mL	4.6241 mL
	20 mM	0.1387 mL	0.6936 mL	1.3872 mL	3.4681 mL
	25 mM	0.1110 mL	0.5549 mL	1.1098 mL	2.7745 mL
	30 mM	0.0925 mL	0.4624 mL	0.9248 mL	2.3121 mL
	40 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7340 mL
	50 mM	0.0555 mL	0.2774 mL	0.5549 mL	1.3872 mL
	60 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1560 mL
	80 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8670 mL
	100 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6936 mL

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IRF1-IN-2

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Cell Death Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) IRF1-IN-2

All Caspase Isoforms

All PARP Isoforms

All Interleukin Related Isoforms

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

IRF1-IN-2 Related Classifications

Cat. No.: HY-171007