708245-32-3
708245-32-3
Chemical Structure
IRF1-IN-2
- CAS No.: 708245-32-3
- Formula:C18H20N2O4S
- Molecular Weight:360.43
InChIKey: PPMHAFZOUWHQPL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(S(=O)(N2CCCC2)=O)C=C1)C3=CC=CC=C3OC
Biological Activity: IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IRF1-IN-2 | 99.83% | IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.64
HY-W775385Metcamifen -
Similarity Score 0.63
HY-Q43097Hsp110-STAT3 PPI-IN-1 -
Similarity Score 0.62
HY-16691AK-7 -
Similarity Score 0.60
HY-W616313Cyprosulfamide -
Similarity Score 0.60
HY-101465RAK-1 (Standard) -
Similarity Score 0.59
HY-B0967Phthalylsulfacetamide -
Similarity Score 0.59
HY-163087PT-91 -
Similarity Score 0.59
HY-160900RN-1665 -
Similarity Score 0.59
HY-121831BDT001 -
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