NGI-235
Based on 1 Customer Validation
NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 2763063-40-5
- Formula: C25H30N4O3S2
- Molecular Weight:498.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR4 |
GLUT1 |
NGI-235 preferentially inhibits OST-A activity, also inhibits OST-B activity[1].
NGI-235 (1-10 μM; 24 h) causes the hypoglycosylation of both TLR4 and GLUT1 in NALM-6 cells overexpressing TLR4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NALM-6 and HEK293T cells
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Concentration:1,, 5, 10 μM
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Incubation Time:24 h
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Result:Caused the hypoglycosylation of both TLR4 and GLUT1.
Chemical Information
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CAS No. 2763063-40-5
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Appearance Solid
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Molecular Weight 498.66
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Formula C25H30N4O3S2
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(S(=O)(N(CC2=CC=CC=C2)C)=O)=CC=C1N(CC3CC3)C)NC4=NC=C(CC)S4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (200.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0054 mL | 10.0269 mL | 20.0537 mL | 50.1344 mL |
| 5 mM | 0.4011 mL | 2.0054 mL | 4.0107 mL | 10.0269 mL | |
| 10 mM | 0.2005 mL | 1.0027 mL | 2.0054 mL | 5.0134 mL | |
| 15 mM | 0.1337 mL | 0.6685 mL | 1.3369 mL | 3.3423 mL | |
| 20 mM | 0.1003 mL | 0.5013 mL | 1.0027 mL | 2.5067 mL | |
| 25 mM | 0.0802 mL | 0.4011 mL | 0.8021 mL | 2.0054 mL | |
| 30 mM | 0.0668 mL | 0.3342 mL | 0.6685 mL | 1.6711 mL | |
| 40 mM | 0.0501 mL | 0.2507 mL | 0.5013 mL | 1.2534 mL | |
| 50 mM | 0.0401 mL | 0.2005 mL | 0.4011 mL | 1.0027 mL | |
| 60 mM | 0.0334 mL | 0.1671 mL | 0.3342 mL | 0.8356 mL | |
| 80 mM | 0.0251 mL | 0.1253 mL | 0.2507 mL | 0.6267 mL | |
| 100 mM | 0.0201 mL | 0.1003 mL | 0.2005 mL | 0.5013 mL |
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