2. Metabolic Enzyme/Protease Anti-infection
  3. Endogenous Metabolite Virus Protease HSV
  4. L-Lysine

L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation.

For research use only. We do not sell to patients.

CAS No. : 56-87-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
Solid
500 mg In-stock
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of L-Lysine:

L-Lysine Related Antibodies

Top Publications Citing Use of Products

    L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.

    L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.

    L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.

    L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.

    L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.

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    Human Endogenous Metabolite Microbial Metabolite

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    HSV-1 HSV-2 HSV

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation[1][2][3][4].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    158 μM
    Compound: 5962
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
    		10.5281/zenodo.6782708
    In Vivo

    L-lysine (5 or 10 mg/kg, p.o., single dose) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model[3]. L-lysine (10 mg/kg, p.o., once daily for 45 days) treatment attenuates pancreatic tissue injury by inhibiting the release of the inflammatory cytokine IL-6, and enhances antioxidant activity in L-Arginine hydrochloride (HY-N0455A)-induced acute pancreatitis mice model[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: L-Arginine hydrochloride (HY-N0455A)-induced acute pancreatitis mice model[4]
    Dosage: 10 mg/kg
    Administration: Oral gavage (p.o.), single dose, pre-treated or post-treated
    Result: Led to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p < 0.001).
    Animal Model: Lipopolysaccharide (HY-D1056) -induced mouse model[4]
    Dosage: 5 mg/kg, 10 mg/kg
    Administration: Oral gavage (p.o.), once daily for 45 days
    Result: Significantly reduced lipid peroxidation, total protein content, lung tissue wet/dry ratio, tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels, myeloperoxidase activity, as well as total cell, neutrophil, and lymphocyte counts.
    Increased the levels of reduced glutathione and the activities of glutathione peroxidase, superoxide dismutase, and catalase.
    Molecular Weight

    146.19

    Formula

    C6H14N2O2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    N[C@@H](CCCCN)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (684.04 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.8404 mL 34.2021 mL 68.4041 mL
    5 mM 1.3681 mL 6.8404 mL 13.6808 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: ≥ 100 mg/mL (684.04 mM); Clear solution

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.94%

    SDS (393 KB)

    COA (242 KB) HNMR (109 KB) RP-HPLC (213 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.8404 mL 34.2021 mL 68.4041 mL 171.0103 mL
    5 mM 1.3681 mL 6.8404 mL 13.6808 mL 34.2021 mL
    10 mM 0.6840 mL 3.4202 mL 6.8404 mL 17.1010 mL
    15 mM 0.4560 mL 2.2801 mL 4.5603 mL 11.4007 mL
    20 mM 0.3420 mL 1.7101 mL 3.4202 mL 8.5505 mL
    25 mM 0.2736 mL 1.3681 mL 2.7362 mL 6.8404 mL
    30 mM 0.2280 mL 1.1401 mL 2.2801 mL 5.7003 mL
    40 mM 0.1710 mL 0.8551 mL 1.7101 mL 4.2753 mL
    50 mM 0.1368 mL 0.6840 mL 1.3681 mL 3.4202 mL
    60 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
    80 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1376 mL
    100 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7101 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Lysine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Lysine56-87-1Endogenous MetaboliteVirus ProteaseHSVHerpes simplex virusAcute pancreatitis mice modelAnti-inflammatory activityAcute pancreatitisAntimicrobial activityInhibitorinhibitorinhibit

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