Cat. No.: HY-N0469

L-Lysine

9 Cited Publications

Customer Review

Based on 9 publication(s) in Google Scholar

L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 56-87-1
Formula: C₆H₁₄N₂O₂
Molecular Weight:146.19

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

L-Lysine Chemical Structure

CAS No.: 56-87-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Publications (9)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All HSV Isoforms :

All Ligands for E3 Ligase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	158 μM Compound: 5962	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells	10.5281/zenodo.6782708
HEK293	EC₅₀	158 μM Compound: 5962	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863) Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)	10.5281/zenodo.6782708

In Vivo

L-lysine (5 or 10 mg/kg, p.o., single dose) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model^[3]. L-lysine (10 mg/kg, p.o., once daily for 45 days) treatment attenuates pancreatic tissue injury by inhibiting the release of the inflammatory cytokine IL-6, and enhances antioxidant activity in L-Arginine hydrochloride (HY-N0455A)-induced acute pancreatitis mice model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

L-Arginine hydrochloride (HY-N0455A)-induced acute pancreatitis mice model^[4]
Dosage:

10 mg/kg
Administration:

Oral gavage (p.o.), single dose, pre-treated or post-treated
Result:

Led to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p < 0.001).

Animal Model:

Lipopolysaccharide (HY-D1056) -induced mouse model^[4]
Dosage:

5 mg/kg, 10 mg/kg
Administration:

Oral gavage (p.o.), once daily for 45 days
Result:

Significantly reduced lipid peroxidation, total protein content, lung tissue wet/dry ratio, tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels, myeloperoxidase activity, as well as total cell, neutrophil, and lymphocyte counts.
Increased the levels of reduced glutathione and the activities of glutathione peroxidase, superoxide dismutase, and catalase.

Chemical Information

CAS No. 56-87-1
Appearance Solid
Molecular Weight 146.19
Formula C₆H₁₄N₂O₂
Color Off-white to yellow
SMILES

N[C@@H](CCCCN)C(O)=O
Structure Classification
- Amino acids
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (9)

All In Vivo Efficacy StudyIFCell Migration/Invasion AssayWBMicrobiological Assay

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Microbiome

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]

2019 Mar 20;7(1):43. PMID: 30890187
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Cell Biochem Biophys

FOXA1 Transcriptional Repression of PLSCR1 Inhibits Tongue Squamous Cell Carcinoma Progression. [Abstract]

2025 May 30. PMID: 40445264
Amino Acids

Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]

2024 Sep 18;56(1):56. PMID: 39292313
J Anim Physiol Anim Nutr

Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis. [Abstract]

2022 Nov;106(6):1420-1430. PMID: 35923149
iMetaOmics

2025 Aug 06.

L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.

L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.

L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.

L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.

L-Lysine purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.
Patent

US20240216332A1.
Laurea Magistrale in Biomedical Engineering, Politecnico di Milano

2019 Jun.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (684.04 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.8404 mL

34.2021 mL

68.4041 mL

5 mM

1.3681 mL

6.8404 mL

13.6808 mL

10 mM

0.6840 mL

3.4202 mL

6.8404 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: ≥ 100 mg/mL (684.04 mM); Clear solution

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

[2]. Santos AMD, et al. Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine. Acta Cir Bras. 2017 Apr;32(4):297-306. [Content Brief]

[3]. Zhang Y, et al. L-lysine ameliorates sepsis-induced acute lung injury in a lipopolysaccharide-induced mouse model. Biomed Pharmacother. 2019 Oct;118:109307. [Content Brief]

[4]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.8404 mL	34.2021 mL	68.4041 mL	171.0103 mL
	5 mM	1.3681 mL	6.8404 mL	13.6808 mL	34.2021 mL
	10 mM	0.6840 mL	3.4202 mL	6.8404 mL	17.1010 mL
	15 mM	0.4560 mL	2.2801 mL	4.5603 mL	11.4007 mL
	20 mM	0.3420 mL	1.7101 mL	3.4202 mL	8.5505 mL
	25 mM	0.2736 mL	1.3681 mL	2.7362 mL	6.8404 mL
	30 mM	0.2280 mL	1.1401 mL	2.2801 mL	5.7003 mL
	40 mM	0.1710 mL	0.8551 mL	1.7101 mL	4.2753 mL
	50 mM	0.1368 mL	0.6840 mL	1.3681 mL	3.4202 mL
	60 mM	0.1140 mL	0.5700 mL	1.1401 mL	2.8502 mL
	80 mM	0.0855 mL	0.4275 mL	0.8551 mL	2.1376 mL
	100 mM	0.0684 mL	0.3420 mL	0.6840 mL	1.7101 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

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L-Lysine

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

FDA-Approved Drug Library

Antiviral Compound Library

Human Endogenous Metabolite Compound Library

Drug Repurposing Compound Library

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Anti-COVID-19 Compound Library

Medicine Food Homology Compound Library

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Mass Spectrometry Human Endogenous Metabolite Library

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Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

Drug Fragment Library

Publications Citing Use of MedChemExpress (MCE) L-Lysine

All Endogenous Metabolite Isoforms

All HSV Isoforms

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Publications (9)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Lysine Related Classifications

HY-N0469 Related Classifications