2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Lysine hydrate

L-Lysine hydrate is an essential amino acid. L-Lysine hydrate can be research for vascular calcification (VC) and acute pancreatitis.

For research use only. We do not sell to patients.

CAS No. : 39665-12-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of L-Lysine hydrate:

L-Lysine hydrate Related Antibodies

Top Publications Citing Use of Products

    L-Lysine hydrate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.

    L-Lysine hydrate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.

    L-Lysine hydrate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.

    L-Lysine hydrate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.

    L-Lysine hydrate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-Lysine hydrate is an essential amino acid. L-Lysine hydrate can be research for vascular calcification (VC) and acute pancreatitis[1][2].

    IC50 & Target[1][2]

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    L-Lysine hydrate (VSMCs) suppresses plasma iPTH and elevates plasma alanine, proline, plasma arginine, and homo arginine, thereby inhibiting apoptosis of VSMCs and mineral precipitation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Lysine hydrate Related Antibodies
    In Vivo

    L-Lysine hydrate (40 μg/kg; p.o.) ameliorates arterial calcification in adenine rats and protects the femora from osteoporotic changes in adenine rats[1].
    L-Lysine hydrate (10 and 400 mg/kg; i.g. and p.o.; Male mice) inhibits pancreatic tissue damage[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice[2]
    Dosage: 10 and 400 mg/kg
    Administration: Intraperitoneal injection and oral administration; for 15 days
    Result: Inhibited the release of the inflammatory cytokine IL-6 and enhance antioxidant activity.
    Molecular Weight

    164.20

    Formula

    C6H16N2O3
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    N[C@H](C(O)=O)CCCCN.O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (609.01 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0901 mL 30.4507 mL 60.9013 mL
    5 mM 1.2180 mL 6.0901 mL 12.1803 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    SDS (393 KB)

    COA (244 KB) HNMR (171 KB) RP-HPLC (215 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.0901 mL 30.4507 mL 60.9013 mL 152.2534 mL
    5 mM 1.2180 mL 6.0901 mL 12.1803 mL 30.4507 mL
    10 mM 0.6090 mL 3.0451 mL 6.0901 mL 15.2253 mL
    15 mM 0.4060 mL 2.0300 mL 4.0601 mL 10.1502 mL
    20 mM 0.3045 mL 1.5225 mL 3.0451 mL 7.6127 mL
    25 mM 0.2436 mL 1.2180 mL 2.4361 mL 6.0901 mL
    30 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0751 mL
    40 mM 0.1523 mL 0.7613 mL 1.5225 mL 3.8063 mL
    50 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0451 mL
    60 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5376 mL
    80 mM 0.0761 mL 0.3806 mL 0.7613 mL 1.9032 mL
    100 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Lysine hydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Lysine39665-12-8Endogenous Metabolitevascular calcificationacute pancreatitisantioxidantInhibitorinhibitorinhibit

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