L-Lysine acetate
Based on 9 publication(s) in Google Scholar
L-Lysine acetate is an essential amino acid. L-Lysine acetate can be research for vascular calcification (VC) and Acute pancreatitis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 57282-49-2
- Formula: C8H18N2O4
- Molecular Weight:206.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) L-Lysine acetate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Cell Biochem Biophys. 2025 May 30. [Abstract]
- Amino Acids. 2024 Sep 18;56(1):56. [Abstract]
- J Anim Physiol Anim Nutr. 2022 Nov;106(6):1420-1430. [Abstract]
- iMetaOmics. 2025 Aug 06.
- Patent. US20240216332A1.
- Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.
Customer Validation & Images
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In Vivo Efficacy Study
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IF
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Cell Migration/Invasion Assay
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WB
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Microbiological Assay
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
L-Lysine acetate (VSMCs) suppresses plasma iPTH and elevates plasma alanine, proline, plasma arginine, and homo arginine, thereby inhibiting apoptosis of VSMCs and mineral precipitation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
L-Lysine acetate (10 and 400 mg/kg; i.g. and p.o.; Male mice) inhibits pancreatic tissue damage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice[2]
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Dosage:10 and 400 mg/kg
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Administration:Intraperitoneal injection and oral administration; for 15 days.
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Result:Inhibited the release of the inflammatory cytokine IL-6 and enhance antioxidant activity.
Chemical Information
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CAS No. 57282-49-2
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Appearance Solid
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Molecular Weight 206.24
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Formula C8H18N2O4
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Color White to off-white
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SMILES
N[C@@H](CCCCN)C(O)=O.CC(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Cell Biochem Biophys
FOXA1 Transcriptional Repression of PLSCR1 Inhibits Tongue Squamous Cell Carcinoma Progression. [Abstract]2025 May 30. PMID: 40445264 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
J Anim Physiol Anim Nutr
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis. [Abstract]2022 Nov;106(6):1420-1430. PMID: 35923149 -
L-Lysine acetate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.
L-Lysine acetate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.
L-Lysine acetate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.
L-Lysine acetate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.
L-Lysine acetate purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.
L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.
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Solvent & Solubility
H2O : 116.67 mg/mL (565.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shimomura A, et, al. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Content Brief]
[2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8487 mL | 24.2436 mL | 48.4872 mL | 121.2180 mL |
| 5 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL | 24.2436 mL | |
| 10 mM | 0.4849 mL | 2.4244 mL | 4.8487 mL | 12.1218 mL | |
| 15 mM | 0.3232 mL | 1.6162 mL | 3.2325 mL | 8.0812 mL | |
| 20 mM | 0.2424 mL | 1.2122 mL | 2.4244 mL | 6.0609 mL | |
| 25 mM | 0.1939 mL | 0.9697 mL | 1.9395 mL | 4.8487 mL | |
| 30 mM | 0.1616 mL | 0.8081 mL | 1.6162 mL | 4.0406 mL | |
| 40 mM | 0.1212 mL | 0.6061 mL | 1.2122 mL | 3.0304 mL | |
| 50 mM | 0.0970 mL | 0.4849 mL | 0.9697 mL | 2.4244 mL | |
| 60 mM | 0.0808 mL | 0.4041 mL | 0.8081 mL | 2.0203 mL | |
| 80 mM | 0.0606 mL | 0.3030 mL | 0.6061 mL | 1.5152 mL | |
| 100 mM | 0.0485 mL | 0.2424 mL | 0.4849 mL | 1.2122 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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