2. PROTAC
  3. PROTAC Linkers
  4. 3-Mercaptopropionic acid NHS ester

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

3-Mercaptopropionic acid NHS ester

3-Mercaptopropionic acid NHS ester Chemical Structure

CAS No. : 117235-10-6

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Based on 1 publication(s) in Google Scholar

3-Mercaptopropionic acid NHS ester Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 3-Mercaptopropionic acid NHS ester

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Mercaptopropionic acid NHS ester Related Antibodies
Molecular Weight

203.22

Formula

C7H9NO4S
CAS No.
Appearance

Liquid (Density: 1.40±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (492.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9208 mL 24.6039 mL 49.2078 mL
5 mM 0.9842 mL 4.9208 mL 9.8416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (466 KB)

COA (249 KB) HNMR (267 KB) MS (78 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9208 mL 24.6039 mL 49.2078 mL 123.0194 mL
5 mM 0.9842 mL 4.9208 mL 9.8416 mL 24.6039 mL
10 mM 0.4921 mL 2.4604 mL 4.9208 mL 12.3019 mL
15 mM 0.3281 mL 1.6403 mL 3.2805 mL 8.2013 mL
20 mM 0.2460 mL 1.2302 mL 2.4604 mL 6.1510 mL
25 mM 0.1968 mL 0.9842 mL 1.9683 mL 4.9208 mL
30 mM 0.1640 mL 0.8201 mL 1.6403 mL 4.1006 mL
40 mM 0.1230 mL 0.6151 mL 1.2302 mL 3.0755 mL
50 mM 0.0984 mL 0.4921 mL 0.9842 mL 2.4604 mL
60 mM 0.0820 mL 0.4101 mL 0.8201 mL 2.0503 mL
80 mM 0.0615 mL 0.3075 mL 0.6151 mL 1.5377 mL
100 mM 0.0492 mL 0.2460 mL 0.4921 mL 1.2302 mL
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3-Mercaptopropionic acid NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Mercaptopropionic acid NHS ester117235-10-6PROTAC LinkersInhibitorinhibitorinhibit

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