2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid  (Synonyms: Fmoc-NH-PEG2-CH2COOH)

Cat. No.: HY-W007713 Purity: 99.73%
COA Handling Instructions

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Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Structure

Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Structure

CAS No. : 166108-71-0

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Based on 1 publication(s) in Google Scholar

Fmoc-8-amino-3,6-dioxaoctanoic acid Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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Description

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Cleavable Linker

 

Alkyl/ether

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-8-amino-3,6-dioxaoctanoic acid Related Antibodies
Molecular Weight

385.41

Formula

C21H23NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (64.87 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5946 mL 12.9732 mL 25.9464 mL
5 mM 0.5189 mL 2.5946 mL 5.1893 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

COA (246 KB) HNMR (270 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5946 mL 12.9732 mL 25.9464 mL 64.8660 mL
5 mM 0.5189 mL 2.5946 mL 5.1893 mL 12.9732 mL
10 mM 0.2595 mL 1.2973 mL 2.5946 mL 6.4866 mL
15 mM 0.1730 mL 0.8649 mL 1.7298 mL 4.3244 mL
20 mM 0.1297 mL 0.6487 mL 1.2973 mL 3.2433 mL
25 mM 0.1038 mL 0.5189 mL 1.0379 mL 2.5946 mL
30 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
40 mM 0.0649 mL 0.3243 mL 0.6487 mL 1.6216 mL
50 mM 0.0519 mL 0.2595 mL 0.5189 mL 1.2973 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
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Fmoc-8-amino-3,6-dioxaoctanoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-8-amino-3,6-dioxaoctanoic acid166108-71-0Fmoc-NH-PEG2-CH2COOHADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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