Fmoc-8-amino-3,6-dioxaoctanoic acid
Based on 1 Customer Validation
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 166108-71-0
- Formula: C21H23NO6
- Molecular Weight:385.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W008016
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Fmoc-Asp(OtBu)-OH -
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Fmoc-NH-PEG8-CH2CH2COOH -
HY-W040289
Mal-amido-PEG2-NHS ester -
HY-100216
SPDP -
HY-134682
Fmoc-NH-PEG5-C2-NH2 -
HY-W040246
Fmoc-NH-PEG6-CH2CH2COOH -
HY-77959
6-Maleimidocapronic acid -
HY-W008568
Fmoc-amino-PEG3-CH2COOH -
HY-130143
Biotin-PEG3-azide -
HY-133063
Fmoc-NH-PEG8-CH2COOH -
HY-W045598
Boc-C16-COOH
All PROTAC Linkers Isoforms
More
Biological Activity
Description
IC50 & Target
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Cleavable Linker |
Alkyl/ether |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 166108-71-0
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Appearance Solid
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Molecular Weight 385.41
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Formula C21H23NO6
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Color White to off-white
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SMILES
O=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
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Synonyms
Fmoc-NH-PEG2-CH2COOH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (64.87 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5946 mL | 12.9732 mL | 25.9464 mL | 64.8660 mL |
| 5 mM | 0.5189 mL | 2.5946 mL | 5.1893 mL | 12.9732 mL | |
| 10 mM | 0.2595 mL | 1.2973 mL | 2.5946 mL | 6.4866 mL | |
| 15 mM | 0.1730 mL | 0.8649 mL | 1.7298 mL | 4.3244 mL | |
| 20 mM | 0.1297 mL | 0.6487 mL | 1.2973 mL | 3.2433 mL | |
| 25 mM | 0.1038 mL | 0.5189 mL | 1.0379 mL | 2.5946 mL | |
| 30 mM | 0.0865 mL | 0.4324 mL | 0.8649 mL | 2.1622 mL | |
| 40 mM | 0.0649 mL | 0.3243 mL | 0.6487 mL | 1.6216 mL | |
| 50 mM | 0.0519 mL | 0.2595 mL | 0.5189 mL | 1.2973 mL | |
| 60 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0811 mL |
Fmoc-8-amino-3,6-dioxaoctanoic acid Related Classifications
HY-W007713 Related Classifications
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