6-Maleimidocapronic acid

Name: 6-Maleimidocapronic acid
Brand: MedChemExpress
SKU: HY-77959
Rating: 4.5 (0 reviews)

Cat. No.: HY-77959 Pureza: 98.0%: Ficha de datos
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6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

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6-Maleimidocapronic acid Estructura química

No. CAS : 55750-53-3

Tamaño	Stock	Cantidad
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtener un presupuesto

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Based on 1 Customer Validation

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTAC Linkers:

Ver todas las isoformas

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

211.21

Fòrmula

C₁₀H₁₃NO₄

No. CAS

55750-53-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCCCC(O)=O)C=CC1=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 200 mg/mL (946.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7346 mL	23.6731 mL	47.3462 mL
5 mM	0.9469 mL	4.7346 mL	9.4692 mL
10 mM	0.4735 mL	2.3673 mL	4.7346 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: ≥98.0%

Select Batch:

Ficha de datos (270 KB) SDS (614 KB)

COA (247 KB) HNMR (122 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7346 mL	23.6731 mL	47.3462 mL	118.3656 mL
	5 mM	0.9469 mL	4.7346 mL	9.4692 mL	23.6731 mL
	10 mM	0.4735 mL	2.3673 mL	4.7346 mL	11.8366 mL
	15 mM	0.3156 mL	1.5782 mL	3.1564 mL	7.8910 mL
	20 mM	0.2367 mL	1.1837 mL	2.3673 mL	5.9183 mL
	25 mM	0.1894 mL	0.9469 mL	1.8938 mL	4.7346 mL
	30 mM	0.1578 mL	0.7891 mL	1.5782 mL	3.9455 mL
	40 mM	0.1184 mL	0.5918 mL	1.1837 mL	2.9591 mL
	50 mM	0.0947 mL	0.4735 mL	0.9469 mL	2.3673 mL
	60 mM	0.0789 mL	0.3946 mL	0.7891 mL	1.9728 mL
	80 mM	0.0592 mL	0.2959 mL	0.5918 mL	1.4796 mL
	100 mM	0.0473 mL	0.2367 mL	0.4735 mL	1.1837 mL