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SPDP (Synonyms: SPDP Crosslinker)

Cat. No.: HY-100216 Purity: 98.45%
Handling Instructions

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

For research use only. We do not sell to patients.

SPDP Chemical Structure

SPDP Chemical Structure

CAS No. : 68181-17-9

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10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
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100 mg USD 252 In-stock
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200 mg USD 432 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

Molecular Weight

312.36

Formula

C₁₂H₁₂N₂O₄S₂

CAS No.

68181-17-9

SMILES

O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 155 mg/mL (496.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2014 mL 16.0072 mL 32.0143 mL
5 mM 0.6403 mL 3.2014 mL 6.4029 mL
10 mM 0.3201 mL 1.6007 mL 3.2014 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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SPDP
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HY-100216
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