68181-17-9
68181-17-9
Chemical Structure
SPDP
Synonym(s): SPDP Crosslinker; Py-ds-Prp-OSu
- CAS No.: 68181-17-9
- Formula:C12H12N2O4S2
- Molecular Weight:312.37
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate
InChIKey: JWDFQMWEFLOOED-UHFFFAOYSA-N
SMILES: O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Biological Activity: SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SPDP | 98.84% | SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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SPDP (Standard) | ≥98% | SPDP (Standard) is the analytical standard of SPDP (HY-100216). This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-12448SPDB -
Similarity Score 0.90
HY-129371SPDV -
Similarity Score 0.88
HY-129374SPDH -
Similarity Score 0.85
HY-W071006PPC-NHS ester -
Similarity Score 0.85
HY-128926SPP -
Similarity Score 0.83
HY-129369SPDMB -
Similarity Score 0.83
HY-129368SPDMV -
Similarity Score 0.80
HY-133542Dimethylamine-SPDB -
Similarity Score 0.76
HY-124377SPDP-C6-NHS ester -
Explore the MedChemAI to find more analogs
References
- [1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [Content Brief]
- [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708. [Content Brief]
