1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. SPP

SPP 

Cat. No.: HY-128926 Purity: 96.41%
Handling Instructions

SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate.

For research use only. We do not sell to patients.

SPP Chemical Structure

SPP Chemical Structure

CAS No. : 341498-08-6

Size Price Stock
100 mg USD 460 Ask For Quote & Lead Time
1 g USD 2299 Ask For Quote & Lead Time

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Description

SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].

IC50 & Target[1]

Cleavable

 

Molecular Weight

340.42

Formula

C₁₄H₁₆N₂O₄S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (293.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9375 mL 14.6877 mL 29.3755 mL
5 mM 0.5875 mL 2.9375 mL 5.8751 mL
10 mM 0.2938 mL 1.4688 mL 2.9375 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SPP
Cat. No.:
HY-128926
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