1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP  (Synonyms: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)

Cat. No.: HY-20336 Purity: 98.80% ee.: 100.00%
COA Handling Instructions

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mc-Val-Cit-PABC-PNP Chemical Structure

Mc-Val-Cit-PABC-PNP Chemical Structure

CAS No. : 159857-81-5

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
50 mg USD 50 In-stock
100 mg USD 65 In-stock
250 mg USD 130 In-stock
500 mg USD 200 Get quote
1 g USD 300 Get quote
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Mc-Val-Cit-PABC-PNP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Protease Cleavable




Molecular Weight







CC(C)[[email protected]@H](C(N[[email protected]@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O


Room temperature in continental US; may vary elsewhere.


4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (50.15 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3555 mL 6.7773 mL 13.5545 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL
10 mM 0.1355 mL 0.6777 mL 1.3555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (6.78 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.78 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.80% ee.: 100.00%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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