1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP (Synonyms: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)

Cat. No.: HY-20336 Purity: 98.80% ee.: 100.00%
Handling Instructions

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mc-Val-Cit-PABC-PNP Chemical Structure

Mc-Val-Cit-PABC-PNP Chemical Structure

CAS No. : 159857-81-5

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Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target



Molecular Weight





CC(C)[[email protected]@H](C(N[[email protected]@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O


Room temperature in continental US; may vary elsewhere.


4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (50.15 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3555 mL 6.7773 mL 13.5545 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL
10 mM 0.1355 mL 0.6777 mL 1.3555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (6.78 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.78 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 98.80% ee.: 100.00%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


Mc-Val-Cit-PABC-PNPMaleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenylADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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