Mc-Val-Cit-PABC-PNP
Based on 6 publication(s) in Google Scholar
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs.
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 159857-81-5
- Formula: C35H43N7O11
- Molecular Weight:737.76
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mc-Val-Cit-PABC-PNP
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Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 159857-81-5
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Appearance Solid
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Molecular Weight 737.76
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Formula C35H43N7O11
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Color Off-white to light yellow
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SMILES
CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
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Synonyms
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (6)
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Journal Impact Factor
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Most Recent
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Front Pharmacol
Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker. [Abstract]2023 Dec 6:14:1320524. PMID: 38125888 -
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Solvent & Solubility
DMSO : 100 mg/mL (135.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3555 mL | 6.7773 mL | 13.5545 mL | 33.8864 mL |
| 5 mM | 0.2711 mL | 1.3555 mL | 2.7109 mL | 6.7773 mL | |
| 10 mM | 0.1355 mL | 0.6777 mL | 1.3555 mL | 3.3886 mL | |
| 15 mM | 0.0904 mL | 0.4518 mL | 0.9036 mL | 2.2591 mL | |
| 20 mM | 0.0678 mL | 0.3389 mL | 0.6777 mL | 1.6943 mL | |
| 25 mM | 0.0542 mL | 0.2711 mL | 0.5422 mL | 1.3555 mL | |
| 30 mM | 0.0452 mL | 0.2259 mL | 0.4518 mL | 1.1295 mL | |
| 40 mM | 0.0339 mL | 0.1694 mL | 0.3389 mL | 0.8472 mL | |
| 50 mM | 0.0271 mL | 0.1355 mL | 0.2711 mL | 0.6777 mL | |
| 60 mM | 0.0226 mL | 0.1130 mL | 0.2259 mL | 0.5648 mL | |
| 80 mM | 0.0169 mL | 0.0847 mL | 0.1694 mL | 0.4236 mL | |
| 100 mM | 0.0136 mL | 0.0678 mL | 0.1355 mL | 0.3389 mL |
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