2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-NH-PEG8-CH2COOH

Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-NH-PEG8-CH2COOH Chemical Structure

Fmoc-NH-PEG8-CH2COOH Chemical Structure

CAS No. : 868594-52-9

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Based on 1 publication(s) in Google Scholar

Fmoc-NH-PEG8-CH2COOH Related Antibodies

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Description

Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

Alkyl/ether

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-NH-PEG8-CH2COOH Related Antibodies
Molecular Weight

649.73

Formula

C33H47NO12
CAS No.
Appearance

Viscous Liquid

Color

Light yellow to brown

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (153.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5391 mL 7.6955 mL 15.3910 mL
5 mM 0.3078 mL 1.5391 mL 3.0782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5391 mL 7.6955 mL 15.3910 mL 38.4775 mL
5 mM 0.3078 mL 1.5391 mL 3.0782 mL 7.6955 mL
10 mM 0.1539 mL 0.7696 mL 1.5391 mL 3.8478 mL
15 mM 0.1026 mL 0.5130 mL 1.0261 mL 2.5652 mL
20 mM 0.0770 mL 0.3848 mL 0.7696 mL 1.9239 mL
25 mM 0.0616 mL 0.3078 mL 0.6156 mL 1.5391 mL
30 mM 0.0513 mL 0.2565 mL 0.5130 mL 1.2826 mL
40 mM 0.0385 mL 0.1924 mL 0.3848 mL 0.9619 mL
50 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7696 mL
60 mM 0.0257 mL 0.1283 mL 0.2565 mL 0.6413 mL
80 mM 0.0192 mL 0.0962 mL 0.1924 mL 0.4810 mL
100 mM 0.0154 mL 0.0770 mL 0.1539 mL 0.3848 mL
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Fmoc-NH-PEG8-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-NH-PEG8-CH2COOH868594-52-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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