Fmoc-NH-PEG8-CH2COOH
Based on 1 Customer Validation
Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 868594-52-9
- Formula: C33H47NO12
- Molecular Weight:649.73
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Cleavable Linker |
PEGs |
Alkyl/ether |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 868594-52-9
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Appearance Viscous Liquid
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Molecular Weight 649.73
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Formula C33H47NO12
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Color Colorless to light yellow
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SMILES
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (153.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5391 mL | 7.6955 mL | 15.3910 mL | 38.4775 mL |
| 5 mM | 0.3078 mL | 1.5391 mL | 3.0782 mL | 7.6955 mL | |
| 10 mM | 0.1539 mL | 0.7696 mL | 1.5391 mL | 3.8478 mL | |
| 15 mM | 0.1026 mL | 0.5130 mL | 1.0261 mL | 2.5652 mL | |
| 20 mM | 0.0770 mL | 0.3848 mL | 0.7696 mL | 1.9239 mL | |
| 25 mM | 0.0616 mL | 0.3078 mL | 0.6156 mL | 1.5391 mL | |
| 30 mM | 0.0513 mL | 0.2565 mL | 0.5130 mL | 1.2826 mL | |
| 40 mM | 0.0385 mL | 0.1924 mL | 0.3848 mL | 0.9619 mL | |
| 50 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.7696 mL | |
| 60 mM | 0.0257 mL | 0.1283 mL | 0.2565 mL | 0.6413 mL | |
| 80 mM | 0.0192 mL | 0.0962 mL | 0.1924 mL | 0.4810 mL | |
| 100 mM | 0.0154 mL | 0.0770 mL | 0.1539 mL | 0.3848 mL |
Fmoc-NH-PEG8-CH2COOH Related Classifications
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