Fmoc-NH-PEG6-CH2COOH
Based on 1 Customer Validation
Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.37%
- CAS No.: 437655-96-4
- Formula: C29H39NO10
- Molecular Weight:561.62
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Cleavable Linker |
Alkyl/ether |
PEGs |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 437655-96-4
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Appearance Liquid (Density: 1.215±0.06 g/cm3)
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Molecular Weight 561.62
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Formula C29H39NO10
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Color Colorless to light yellow
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SMILES
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (178.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7806 mL | 8.9028 mL | 17.8056 mL | 44.5141 mL |
| 5 mM | 0.3561 mL | 1.7806 mL | 3.5611 mL | 8.9028 mL | |
| 10 mM | 0.1781 mL | 0.8903 mL | 1.7806 mL | 4.4514 mL | |
| 15 mM | 0.1187 mL | 0.5935 mL | 1.1870 mL | 2.9676 mL | |
| 20 mM | 0.0890 mL | 0.4451 mL | 0.8903 mL | 2.2257 mL | |
| 25 mM | 0.0712 mL | 0.3561 mL | 0.7122 mL | 1.7806 mL | |
| 30 mM | 0.0594 mL | 0.2968 mL | 0.5935 mL | 1.4838 mL | |
| 40 mM | 0.0445 mL | 0.2226 mL | 0.4451 mL | 1.1129 mL | |
| 50 mM | 0.0356 mL | 0.1781 mL | 0.3561 mL | 0.8903 mL | |
| 60 mM | 0.0297 mL | 0.1484 mL | 0.2968 mL | 0.7419 mL | |
| 80 mM | 0.0223 mL | 0.1113 mL | 0.2226 mL | 0.5564 mL | |
| 100 mM | 0.0178 mL | 0.0890 mL | 0.1781 mL | 0.4451 mL |
Fmoc-NH-PEG6-CH2COOH Related Classifications
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