Fmoc-NH-PEG6-CH2COOH

Name: Fmoc-NH-PEG6-CH2COOH
Brand: MedChemExpress
SKU: HY-130364
Rating: 4.5 (0 reviews)

製品番号: HY-130364 純度: 99.37%: Data Sheet SDS COA 取扱説明書
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Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-NH-PEG6-CH2COOH 構造式

CAS 番号 : 437655-96-4

容量	価格（税別）	在庫状況	数量
100 mg	$50	在庫あり	Estimated Time of Arrival: December 31
250 mg	$68	在庫あり	Estimated Time of Arrival: December 31
1 g	$235	在庫あり	Estimated Time of Arrival: December 31
5 g	$1140	在庫あり	Estimated Time of Arrival: December 31
10 g	$1945	在庫あり	Estimated Time of Arrival: December 31
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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

Cleavable Linker

Alkyl/ether

PEGs

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

561.62

分子式

C₂₉H₃₉NO₁₀

CAS 番号

437655-96-4

Appearance

Liquid (Density: 1.215±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCC(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (178.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7806 mL	8.9028 mL	17.8056 mL
5 mM	0.3561 mL	1.7806 mL	3.5611 mL
10 mM	0.1781 mL	0.8903 mL	1.7806 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.37%

Select Batch:

データシート (267 KB) SDS (393 KB)

COA (241 KB) HNMR (133 KB) RP-HPLC (235 KB) LCMS (332 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7806 mL	8.9028 mL	17.8056 mL	44.5141 mL
	5 mM	0.3561 mL	1.7806 mL	3.5611 mL	8.9028 mL
	10 mM	0.1781 mL	0.8903 mL	1.7806 mL	4.4514 mL
	15 mM	0.1187 mL	0.5935 mL	1.1870 mL	2.9676 mL
	20 mM	0.0890 mL	0.4451 mL	0.8903 mL	2.2257 mL
	25 mM	0.0712 mL	0.3561 mL	0.7122 mL	1.7806 mL
	30 mM	0.0594 mL	0.2968 mL	0.5935 mL	1.4838 mL
	40 mM	0.0445 mL	0.2226 mL	0.4451 mL	1.1129 mL
	50 mM	0.0356 mL	0.1781 mL	0.3561 mL	0.8903 mL
	60 mM	0.0297 mL	0.1484 mL	0.2968 mL	0.7419 mL
	80 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5564 mL
	100 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.4451 mL