Copy Link Print Information

TGN-020

25 Cited Publications
Customer Review

Based on 25 publication(s) in Google Scholar

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 51987-99-6
  • Formula: C8H6N4OS
  • Molecular Weight:206.23
  • Storage:

    Store at room temperature 3 years.

    In solvent   -80°C, 2 years , -20°C, 1 year
  • TGN-020 Chemical Structure
    TGN-020 Chemical Structure
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
CAS No.: 51987-99-6
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of TGN-020:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) TGN-020

More
Customer Validation & Images
In Vivo Efficacy StudyHistological Imaging/StainingIFWB
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • WB
  • WB
  • IF
  • Histological Imaging/Staining

All PROTAC Linkers Isoforms

More
Keywords
100 mg

Get Quote In-stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • TGN-020 Chemical Structure
    TGN-020 Chemical Structure
    1/16
  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative T2WI and DWI images of three distinct mouse groups.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     Schematic of intracerebral injection procedure in mice. Representative fluorescence microscopy images show Ovalbumin (45-kDa, red) inflow into CSF at 30- and 60-minute. The white arrow indicates the residual tracer deposition. Scale bar: 1000 μm. Quantification of Ovalbumin inflow at 30- and 60-minute in brain sections (n = 4 mice per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative Western blot bands and densitometric quantification of AQP4-M1 and AQP4-M23 in the peri-infarction area (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p.,on the third day) Representative immunoblot bands and densitometric quantification of TH, GFAP, AQP4-M1, AQP4-M23, and AQP4-M23/M1 (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p., on the third day).Representative 20 × magnification immunofluorescence images of AQP4 (red) and GFAP (green) in the striatum and SN. White dotted squares show the colocalization of AQP4 with astrocyte endfeet.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     Quantification of the mean intensity of A594 penetration into the whole brain parenchyma in both Saline and MPTP groups after inhibition of TGN-020 (100 mg/kg, i.p., on the third day) (n = 4–5 per group).

  • TGN-020