51987-99-6
51987-99-6
Chemical Structure
TGN-020
- CAS No.: 51987-99-6
- Formula:C8H6N4OS
- Molecular Weight:206.23
IUPAC Name: N-(1,3,4-thiadiazol-2-yl)nicotinamide
InChIKey: AGEGZHOPKZFKBP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1)NC2=NN=CS2
Biological Activity: TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TGN-020 | 99.97% | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats. | ||||||||||||||||||||
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References
- [1]. Vincent J Huber, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7. [Content Brief]
- [2]. Shou Oosuka, et al. Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina. Int J Mol Sci. 2020 Mar 27;21(7):2324. [Content Brief]
- [3]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]
- [4]. Jian Li, et al. TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats. Life Sci. 2019 Apr 1;222:148-157. [Content Brief]
