IMPDH-IN-4
Based on 1 Customer Validation
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 2427862-70-0
- Formula: C10H8N2OS
- Molecular Weight:204.25
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
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Biological Activity
IMPDH-IN-4 (Compound 9) has no significant inhibition of NAD synthesis (IC50 = 48 μM), does not inhibit NAMPT activity and NMN level in S462 cells[1].
IMPDH-IN-4 has toxic to S462 cells (IC50 = 1.20 μM) and Cas9-expressing HCT116 cells (IC50 = 20.8 nM)[1].
IMPDH-IN-4 (30 days) depends on NAMPT and NMNAT1 to accomplish activity in knock out NMNAT1 in both HCT116 and S462 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | AUClast | Vz-F_obs |
|---|---|---|---|---|---|---|
| Mice[1] | 5 mg/kg | i.v. | 5 min | 2095 ng/mL | 150026 min·ng/mL | 36766 mL |
Chemical Information
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CAS No. 2427862-70-0
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Appearance Solid
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Molecular Weight 204.25
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Formula C10H8N2OS
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=CS1)C2=CN=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (24.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8960 mL | 24.4798 mL | 48.9596 mL | 122.3990 mL |
| 5 mM | 0.9792 mL | 4.8960 mL | 9.7919 mL | 24.4798 mL | |
| 10 mM | 0.4896 mL | 2.4480 mL | 4.8960 mL | 12.2399 mL | |
| 15 mM | 0.3264 mL | 1.6320 mL | 3.2640 mL | 8.1599 mL | |
| 20 mM | 0.2448 mL | 1.2240 mL | 2.4480 mL | 6.1200 mL |
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