IMPDH-IN-4
Based on 1 Customer Validation
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 2427862-70-0
- 分子式: C10H8N2OS
- 分子量:204.25
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IMPDH-IN-4 (Compound 9) has no significant inhibition of NAD synthesis (IC50 = 48 μM), does not inhibit NAMPT activity and NMN level in S462 cells[1].
IMPDH-IN-4 has toxic to S462 cells (IC50 = 1.20 μM) and Cas9-expressing HCT116 cells (IC50 = 20.8 nM)[1].
IMPDH-IN-4 (30 days) depends on NAMPT and NMNAT1 to accomplish activity in knock out NMNAT1 in both HCT116 and S462 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | AUClast | Vz-F_obs |
|---|---|---|---|---|---|---|
| Mice[1] | 5 mg/kg | i.v. | 5 min | 2095 ng/mL | 150026 min·ng/mL | 36766 mL |
化学情報
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CAS 番号 2427862-70-0
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性状 Solid
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分子量 204.25
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分子式 C10H8N2OS
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=CS1)C2=CN=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (24.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8960 mL | 24.4798 mL | 48.9596 mL | 122.3990 mL |
| 5 mM | 0.9792 mL | 4.8960 mL | 9.7919 mL | 24.4798 mL | |
| 10 mM | 0.4896 mL | 2.4480 mL | 4.8960 mL | 12.2399 mL | |
| 15 mM | 0.3264 mL | 1.6320 mL | 3.2640 mL | 8.1599 mL | |
| 20 mM | 0.2448 mL | 1.2240 mL | 2.4480 mL | 6.1200 mL |
IMPDH-IN-4 関連分類
HY-161712 関連分類
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