2427862-70-0
Chemical Structure
IMPDH-IN-4
- CAS No.: 2427862-70-0
- Formula:C10H8N2OS
- Molecular Weight:204.25
InChIKey: IUPJMFUIKHKWKL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CS1)C2=CN=CC=C2
Biological Activity: IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers[1].
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IMPDH-IN-4 | 99.76% | IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers. | ||||||||||||||||||||
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Keywords
