2. Anti-infection Epigenetics Cell Cycle/DNA Damage
  3. HCV HDAC
  4. Nicoxamat

Nicoxamat  (Synonyms: N-Hydroxynicotinamide)

Cat. No.: HY-W555601 Purity: 99.05%
COA
Handling Instructions Technical Support

Nicoxamat (N-Hydroxynicotinamide) is a HCV inhibitor as well as a selective HDAC6 inhibitor. Nicoxamat is applicable to research related to hepatitis C virus (HCV) infection.

For research use only. We do not sell to patients.

Nicoxamat

Nicoxamat Chemical Structure

CAS No. : 5657-61-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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Nicoxamat Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nicoxamat (N-Hydroxynicotinamide) is a HCV inhibitor as well as a selective HDAC6 inhibitor. Nicoxamat is applicable to research related to hepatitis C virus (HCV) infection[1].

IC50 & Target[1]

HDAC6

 

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
450 μM
Compound: II
Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
[PMID: 25937017]
In Vitro

Nicoxamat (compound IIa) inhibits the proliferation of HCV full-length genomic replicons in Huh7 luc/neo cells, with an EC50 of 25 μM, a CC50 of 450 μM, and a selectivity index of 18[1].
Nicoxamat (20-100 μM) induces concentration-dependent hyperacetylation of α-tubulin in Huh7-luc/neo cells[1].
Nicoxamat (100 μM; 72 h) does not induce significant histone H3 acetylation in Huh7-luc/neo cells, indicating its selectivity for class I HDACs[1].
Nicoxamat (0-100 μM) exhibits concentration-dependent inhibition of HCV replicon and HDAC6 inhibitory activity in Huh7-luc/neo cells, with its HCV inhibitory activity being stronger than HDAC6 inhibitory activity at low concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicoxamat Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh7-luc/neo cells
Concentration: 100 μM
Incubation Time: 72 h
Result: Did not cause a significant increase in acetylated histone H3 levels at 100 μM after 72 hours of incubation.
Molecular Weight

138.13

Formula

C6H6N2O2
CAS No.
Appearance

Solid

SMILES

O=C(NO)C=1C=NC=CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (180.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2396 mL 36.1978 mL 72.3956 mL
5 mM 1.4479 mL 7.2396 mL 14.4791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.05%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.2396 mL 36.1978 mL 72.3956 mL 180.9889 mL
5 mM 1.4479 mL 7.2396 mL 14.4791 mL 36.1978 mL
10 mM 0.7240 mL 3.6198 mL 7.2396 mL 18.0989 mL
15 mM 0.4826 mL 2.4132 mL 4.8264 mL 12.0659 mL
20 mM 0.3620 mL 1.8099 mL 3.6198 mL 9.0494 mL
25 mM 0.2896 mL 1.4479 mL 2.8958 mL 7.2396 mL
30 mM 0.2413 mL 1.2066 mL 2.4132 mL 6.0330 mL
40 mM 0.1810 mL 0.9049 mL 1.8099 mL 4.5247 mL
50 mM 0.1448 mL 0.7240 mL 1.4479 mL 3.6198 mL
60 mM 0.1207 mL 0.6033 mL 1.2066 mL 3.0165 mL
80 mM 0.0905 mL 0.4525 mL 0.9049 mL 2.2624 mL
100 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8099 mL
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Nicoxamat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicoxamat5657-61-4N-HydroxynicotinamideHCVHDACHepatitis C virusHistone deacetylasesHuh7 luc/neo cellshistone H3α-tubulinclass I HDACshepatitis c viruspoliovirusHDAC6Inhibitorinhibitorinhibit

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